25(R)-Hydroxyprotopanaxadiol

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25(R)-Hydroxyprotopanaxadiol is a Triterpenoids product that can be isolated from the roots of Panax ginseng C. A. Mey..

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25(R)-Hydroxyprotopanaxadiol Chemical Structure

CAS No. : 83349-37-5

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Biological Activity
Purity & Documentation
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Description

25(R)-Hydroxyprotopanaxadiol is a Triterpenoids product that can be isolated from the roots of Panax ginseng C. A. Mey.^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	22.69 μM Compound: AD-2	Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
A549	IC₅₀	27.91 μM Compound: 2; 25-OH-PPD	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
A549	IC₅₀	29.87 μM Compound: 25-OH-PPD	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 21216145]
A549	IC₅₀	34.2 μM Compound: 25-OH-PPD	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22840493]
A549	IC₅₀	5.9 μM Compound: 1; 25-OH-PPD	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 28073676]
BGC-823	IC₅₀	33.2 μM Compound: 1; 25-OH-PPD	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay	[PMID: 28073676]
BGC-823	IC₅₀	44.2 μM Compound: AD-2, 25-OH-PPD	Antiproliferative activity against human BGC823 cells assessed as cell-growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells assessed as cell-growth inhibition after 48 hrs by MTT assay	[PMID: 25453794]
BGC-823	IC₅₀	46 μM Compound: 25-OH-PPD; AD-2	Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTT assay	10.1039/C5MD00382B
COLO 205	IC₅₀	18.86 μM Compound: 25-OH-PPD	Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay Cytotoxicity against human COLO205 cells after 72 hrs by MTT assay	[PMID: 21216145]
DU-145	IC₅₀	53 μM Compound: 25-OH-PPD; AD-2	Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay	10.1039/C5MD00382B
DU-145	IC₅₀	57.9 μM Compound: 25-OH-PPD	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27561718]
HCT-116	IC₅₀	21.5 μM Compound: 1; 25-OH-PPD	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 28073676]
HCT-116	IC₅₀	33.3 μM Compound: AD-2, 25-OH-PPD	Antiproliferative activity against human HCT116 cells assessed as cell-growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells assessed as cell-growth inhibition after 48 hrs by MTT assay	[PMID: 25453794]
HeLa	IC₅₀	19.6 μM Compound: 2; 25-OH-PPD	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
HeLa	IC₅₀	46.4 μM Compound: 25-OH-PPD	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 27561718]
HeLa	IC₅₀	48.6 μM Compound: AD-2, 25-OH-PPD	Antiproliferative activity against human HeLa cells assessed as cell-growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell-growth inhibition after 48 hrs by MTT assay	[PMID: 25453794]
HepG2	IC₅₀	45.83 μM Compound: 25-OH-PPD	Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells after 72 hrs by MTT assay	[PMID: 21216145]
HL-60	IC₅₀	8.03 μM Compound: 25-OH-PPD	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	[PMID: 21216145]
LoVo	IC₅₀	45.2 μM Compound: 25-OH-PPD	Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay Antiproliferative activity against human LoVo cells after 48 hrs by MTT assay	[PMID: 22840493]
LoVo	IC₅₀	46.7 μM Compound: AD-2, 25-OH-PPD	Antiproliferative activity against human LoVo cells assessed as cell-growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human LoVo cells assessed as cell-growth inhibition after 48 hrs by MTT assay	[PMID: 25453794]
MCF7	IC₅₀	28.52 μM Compound: AD-2	Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
MCF7	IC₅₀	34.16 μM Compound: 25-OH-PPD	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21216145]
MCF7	IC₅₀	48.9 μM Compound: 25-OH-PPD	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22840493]
MCF7	IC₅₀	49.58 μM Compound: 2; 25-OH-PPD	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
MCF7	IC₅₀	49.6 μM Compound: AD-2, 25-OH-PPD	Antiproliferative activity against human MCF7 cells assessed as cell-growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell-growth inhibition after 48 hrs by MTT assay	[PMID: 25453794]
MCF7	IC₅₀	7.5 μM Compound: 1; 25-OH-PPD	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28073676]
MDA-MB-231	IC₅₀	33 μM Compound: 25-OH-PPD; AD-2	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	10.1039/C5MD00382B
MGC-803	IC₅₀	69.83 μM Compound: AD-2	Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
PC-3	IC₅₀	45.66 μM Compound: AD-2	Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
PC-3	IC₅₀	57 μM Compound: 25-OH-PPD; AD-2	Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay	10.1039/C5MD00382B
SGC-7901	IC₅₀	34 μM Compound: AD-2	Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay	[PMID: 31862444]
U-87MG ATCC	IC₅₀	25.06 μM Compound: 2; 25-OH-PPD	Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human U87 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 30568759]
U-87MG ATCC	IC₅₀	27.5 μM Compound: AD-2, 25-OH-PPD	Antiproliferative activity against human U87 cells assessed as cell-growth inhibition after 48 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as cell-growth inhibition after 48 hrs by MTT assay	[PMID: 25453794]

Molecular Weight

478.75

Formula

C₃₀H₅₄O₄

CAS No.

83349-37-5

SMILES

C[C@]12[C@@](C[C@H]([C@@]3([H])[C@]2(CC[C@]3([H])[C@](C)(O)CCCC(C)(O)C)C)O)([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC1)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)