2A3 

2A3 is a highly efficient and precise SHAPE reagent with powerful biomembrane penetration capabilities, suitable for both in vivo and in vitro RNA structure detection. 2A3 can not only effectively probe most RNA loops but also better capture local nucleotide dynamics, thus enabling it to readily detect regions of ribonucleoprotein complexes that are typically inaccessible to other compounds^[1].

188.19

C₉H₈N₄O

2765091-45-8

Solid

White to off-white

O=C(C1=CC=CN=C1N)N2C=NC=C2

Room temperature in continental US; may vary elsewhere.

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Marinus T, et al. A novel SHAPE reagent enables the analysis of RNA structure in living cells with unprecedented accuracy[J]. Nucleic acids research, 2021, 49(6): e34-e34.  [Content Brief]