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  3. Biochemical Assay Reagents
  4. 2A3

2A3 is a highly efficient and precise SHAPE reagent with powerful biomembrane penetration capabilities, suitable for both in vivo and in vitro RNA structure detection. 2A3 can not only effectively probe most RNA loops but also better capture local nucleotide dynamics, thus enabling it to readily detect regions of ribonucleoprotein complexes that are typically inaccessible to other compounds.

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2A3 Chemical Structure

2A3 Chemical Structure

CAS No. : 2765091-45-8

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2A3 Related Antibodies

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Description

2A3 is a highly efficient and precise SHAPE reagent with powerful biomembrane penetration capabilities, suitable for both in vivo and in vitro RNA structure detection. 2A3 can not only effectively probe most RNA loops but also better capture local nucleotide dynamics, thus enabling it to readily detect regions of ribonucleoprotein complexes that are typically inaccessible to other compounds[1].

Molecular Weight

188.19

Formula

C9H8N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CN=C1N)N2C=NC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (464.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3138 mL 26.5689 mL 53.1378 mL
5 mM 1.0628 mL 5.3138 mL 10.6276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.3138 mL 26.5689 mL 53.1378 mL 132.8445 mL
5 mM 1.0628 mL 5.3138 mL 10.6276 mL 26.5689 mL
10 mM 0.5314 mL 2.6569 mL 5.3138 mL 13.2844 mL
15 mM 0.3543 mL 1.7713 mL 3.5425 mL 8.8563 mL
20 mM 0.2657 mL 1.3284 mL 2.6569 mL 6.6422 mL
25 mM 0.2126 mL 1.0628 mL 2.1255 mL 5.3138 mL
30 mM 0.1771 mL 0.8856 mL 1.7713 mL 4.4281 mL
40 mM 0.1328 mL 0.6642 mL 1.3284 mL 3.3211 mL
50 mM 0.1063 mL 0.5314 mL 1.0628 mL 2.6569 mL
60 mM 0.0886 mL 0.4428 mL 0.8856 mL 2.2141 mL
80 mM 0.0664 mL 0.3321 mL 0.6642 mL 1.6606 mL
100 mM 0.0531 mL 0.2657 mL 0.5314 mL 1.3284 mL
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2A3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2A32765091-45-8Biochemical Assay ReagentsSelective 2'-Hydroxyl Acylation analyzed by Primer Extension (SHAPE)RNA structure detectionInhibitorinhibitorinhibit

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