2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (2R,4R)-APDC

(2R,4R)-APDC  (Synonyms: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid)

Cat. No.: HY-102091
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(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases.

For research use only. We do not sell to patients.

(2R,4R)-APDC Chemical Structure

(2R,4R)-APDC Chemical Structure

CAS No. : 169209-63-6

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Based on 1 publication(s) in Google Scholar

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(2R,4R)-APDC Related Antibodies

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Description

(2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases[1][2].

IC50 & Target[1]

group II mGlu receptors

 

Cellular Effect
Cell Line Type Value Description References
HEK293 EC50
> 100 μM
Compound: 18
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive
[PMID: 15801843]
In Vivo

2R, 4R-APDC (1-10 nmol; ICV; daily for 14 days) decreases cell proliferation in the dentate gyrus[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats weighing between 300 and 350 g[2]
Dosage: 1 nmol/10 μl; 10 nmol/10μl
Administration: ICV; daily for 14 days
Result: Resulted in decreased BrdU-immunoreactive cells in the DG.
Molecular Weight

174.15

Formula

C6H10N2O4
CAS No.
SMILES

O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(2R,4R)-APDC Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(2R,4R)-APDC169209-63-6(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acidmGluRMetabotropic glutamate receptorsanticonvulsantneuroprotectivecellproliferationdentategyrusInhibitorinhibitorinhibit

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