2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Endogenous Metabolite
  4. 3'-Deoxyuridine-5'-triphosphate trisodium

3'-Deoxyuridine-5'-triphosphate trisodium  (Synonyms: 3'-dUTP trisodium)

Cat. No.: HY-135780A Purity: 99.69%
COA Handling Instructions

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3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM.

For research use only. We do not sell to patients.

3'-Deoxyuridine-5'-triphosphate trisodium Chemical Structure

3'-Deoxyuridine-5'-triphosphate trisodium Chemical Structure

Size Price Stock Quantity
1 mg USD 950 In-stock
5 mg USD 1950 In-stock
10 mg USD 3200 In-stock
25 mg USD 6400 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of 3'-Deoxyuridine-5'-triphosphate trisodium:

3'-Deoxyuridine-5'-triphosphate trisodium Related Antibodies

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  • Purity & Documentation

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Description

3'-Deoxyuridine-5'-triphosphate trisodium (3'-dUTP trisodium) is a nucleotide analogue that inhibits DNA-dependent RNA polymerases I and II. 3'-Deoxyuridine-5'-triphosphate trisodium strongly and competitively inhibits the incorporations of UTP into RNA with a Ki value of 2.0 μM[1].

In Vitro

3'-Deoxyuridine-5'-triphosphate (3'-dUTP) is synthesized starting from cordycepin in good yield. 3'-Deoxyuridine-5'-triphosphate strongly and competitively inhibits the incorporations of UTP into RNA by the RNA polymerases. 3'-Deoxyuridine-5'-triphosphate will be useful in studies at the molecular level on the relationship of template and substrate in RNA synthesis with chromatin, isolated nuclei or permeable cells, because it does not have any effect on poly (rA) synthesis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3'-Deoxyuridine-5'-triphosphate trisodium Related Antibodies
Molecular Weight

534.09

Formula

C9H12N2Na3O14P3
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=P(O)(O[Na])OP(OP(OC[C@@H](O1)C[C@@H](O)[C@@H]1N2C(NC(C=C2)=O)=O)(O[Na])=O)(O[Na])=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (37.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8723 mL 9.3617 mL 18.7234 mL
5 mM 0.3745 mL 1.8723 mL 3.7447 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (93.62 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.69%

COA (253 KB) HNMR (129 KB) LCMS (269 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8723 mL 9.3617 mL 18.7234 mL 46.8086 mL
5 mM 0.3745 mL 1.8723 mL 3.7447 mL 9.3617 mL
10 mM 0.1872 mL 0.9362 mL 1.8723 mL 4.6809 mL
15 mM 0.1248 mL 0.6241 mL 1.2482 mL 3.1206 mL
20 mM 0.0936 mL 0.4681 mL 0.9362 mL 2.3404 mL
25 mM 0.0749 mL 0.3745 mL 0.7489 mL 1.8723 mL
30 mM 0.0624 mL 0.3121 mL 0.6241 mL 1.5603 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3'-Deoxyuridine-5'-triphosphate trisodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3'-Deoxyuridine-5'-triphosphate trisodium3'-dUTP trisodiumNucleoside Antimetabolite/AnalogDNA/RNA SynthesisEndogenous MetaboliteInhibitorinhibitorinhibit

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