2. Others Protein Tyrosine Kinase/RTK
  3. Isotope-Labeled Compounds FLT3
  4. 3-Hydroxy Midostaurin-d5

3-Hydroxy Midostaurin-d5  (Synonyms: CGP52421-d5)

Cat. No.: HY-108263S
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3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

For research use only. We do not sell to patients.

3-Hydroxy Midostaurin-d<sub>5</sub> Chemical Structure

3-Hydroxy Midostaurin-d5 Chemical Structure

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3-Hydroxy Midostaurin-d5 Related Antibodies

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Description

3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].

Molecular Weight

591.67

Formula

C35H25D5N4O5
Unlabeled CAS

179237-49-1
SMILES

OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C(C([2H])=C9[2H])=C(C([2H])=C9[2H])[2H])=O)C)C)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
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3-Hydroxy Midostaurin-d5 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxy Midostaurin-d5CGP52421-d5Isotope-Labeled CompoundsFLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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