3-Hydroxyglutaric acid-d₅

Name: 3-Hydroxyglutaric acid-d 5
Brand: MedChemExpress
SKU: HY-113411S
Rating: 4.5 (1 reviews)

Cat. No.: HY-113411S Purity: 99.42%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

3-Hydroxyglutaric acid-d₅ is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative[1][2].

For research use only. We do not sell to patients.

3-Hydroxyglutaric acid-d<sub>5</sub> Chemical Structure

3-Hydroxyglutaric acid-d₅ Chemical Structure

CAS No. : 1219805-72-7

Size	Price	Stock	Quantity
1 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 3-Hydroxyglutaric acid-d₅:

3-Hydroxyglutaric acid Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

3-Hydroxyglutaric acid-d₅ is the deuterium labeled 3-Hydroxyglutaric acid. 3-Hydroxyglutaric acid is a glutaric acid derivative[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

153.14

Formula

C₅H₃D₅O₅

CAS No.

1219805-72-7

Unlabeled CAS

638-18-6

Appearance

Solid

Color

White to off-white

SMILES

OC(C([2H])([2H])C(O)([2H])C([2H])([2H])C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (1632.49 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5300 mL	32.6499 mL	65.2997 mL
5 mM	1.3060 mL	6.5300 mL	13.0599 mL
10 mM	0.6530 mL	3.2650 mL	6.5300 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.42%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) RP-HPLC (210 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Rosa RB, et al. Evidence that 3-hydroxyglutaric acid interacts with NMDA receptors in synaptic plasma membranes from cerebral cortex of young rats. Neurochem Int. 2004 Dec;45(7):1087-94. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O	1 mM	6.5300 mL	32.6499 mL	65.2997 mL	163.2493 mL
	5 mM	1.3060 mL	6.5300 mL	13.0599 mL	32.6499 mL
	10 mM	0.6530 mL	3.2650 mL	6.5300 mL	16.3249 mL
	15 mM	0.4353 mL	2.1767 mL	4.3533 mL	10.8833 mL
	20 mM	0.3265 mL	1.6325 mL	3.2650 mL	8.1625 mL
	25 mM	0.2612 mL	1.3060 mL	2.6120 mL	6.5300 mL
	30 mM	0.2177 mL	1.0883 mL	2.1767 mL	5.4416 mL
	40 mM	0.1632 mL	0.8162 mL	1.6325 mL	4.0812 mL
	50 mM	0.1306 mL	0.6530 mL	1.3060 mL	3.2650 mL
	60 mM	0.1088 mL	0.5442 mL	1.0883 mL	2.7208 mL
	80 mM	0.0816 mL	0.4081 mL	0.8162 mL	2.0406 mL
	100 mM	0.0653 mL	0.3265 mL	0.6530 mL	1.6325 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.