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  4. 3-Hydroxymethyl-β-carboline

3-Hydroxymethyl-β-carboline antagonizes the anxiolytic and anticonvulsant actions of Diazepam and reverses the sedative action of Flurazepam. 3-Hydroxymethyl-β-carboline also antagonizes the cerebrovascular and cerebral metabolic depression produced by Flurazepam.

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3-Hydroxymethyl-β-carboline Chemical Structure

3-Hydroxymethyl-β-carboline Chemical Structure

CAS No. : 65474-79-5

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3-Hydroxymethyl-β-carboline Related Antibodies

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Description

3-Hydroxymethyl-β-carboline antagonizes the anxiolytic and anticonvulsant actions of Diazepam and reverses the sedative action of Flurazepam. 3-Hydroxymethyl-β-carboline also antagonizes the cerebrovascular and cerebral metabolic depression produced by Flurazepam[1][2].

Cellular Effect
Cell Line Type Value Description References
A498 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human A498 cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
COLO 205 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human COLO205 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human COLO205 cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
Detroit 551 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human Detroit 551 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human Detroit 551 cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
Hep 3B2 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human Hep3B cells incubated for 48 hrs by MTT assay
Cytotoxicity against human Hep3B cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
HL-60 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human HL60 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human HL60 cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
NCI-H460 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human H460 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human H460 cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
SK-OV-3 IC50
> 100 μM
Compound: 9b
Cytotoxicity against human SKOV3 cells incubated for 48 hrs by MTT assay
Cytotoxicity against human SKOV3 cells incubated for 48 hrs by MTT assay
[PMID: 26235951]
Molecular Weight

198.22

Formula

C12H10N2O
CAS No.
SMILES

C1=CC=C2C(=C1)C3=C(C=NC(=C3)CO)N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3-Hydroxymethyl-β-carboline Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxymethyl-β-carboline65474-79-5OthersDiazepamFlurazepamanxiolyticanticonvulsantInhibitorinhibitorinhibit

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