3-Hydroxyterphenyllin (Synonyms: NSC 299113)

Cat. No.: HY-N10268: FAQs
Data Sheet Handling Instructions

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3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer.

For research use only. We do not sell to patients.

3-Hydroxyterphenyllin Chemical Structure

CAS No. : 66163-76-6

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5 mg		Get quote	Estimated Time of Arrival: December 31

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	34.68 μM Compound: 11	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 21486068]
HL-60	IC₅₀	9.86 μM Compound: 11	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 21486068]
P388	IC₅₀	28.06 μM Compound: 11	Cytotoxicity against mouse P388 cells by MTT assay Cytotoxicity against mouse P388 cells by MTT assay	[PMID: 21486068]

Molecular Weight

354.35

Formula

C₂₀H₁₈O₆

CAS No.

66163-76-6

SMILES

OC1=CC=C(C2=CC(OC)=C(C3=CC=C(C(O)=C3)O)C(O)=C2OC)C=C1

Structure Classification

Initial Source

Microorganisms

Aspergillus candidus LINK

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kurobane I, et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by H and C nuclear magnetic resonance spectroscopy. J Antibiot (Tokyo). 1979;32(6):559-564. [Content Brief]

[2]. Wang Y, et al. 3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells. Int J Oncol. 2017;50(4):1392-1402. [Content Brief]

3-Hydroxyterphenyllin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Hydroxyterphenyllin66163-76-6NSC 299113NSC299113NSC-299113ApoptosisAspergillus candidusproliferationcytotoxicityS phase arrestapoptosisovarian cancerInhibitorinhibitorinhibit

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