2. PI3K/Akt/mTOR
  3. PIN1
  4. 3-Pyridine toxoflavin

3-Pyridine toxoflavin (compound 49) is a PIN1 inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder.

For research use only. We do not sell to patients.

3-Pyridine toxoflavin Chemical Structure

3-Pyridine toxoflavin Chemical Structure

CAS No. : 32502-20-8

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3-Pyridine toxoflavin Related Antibodies

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Description

3-Pyridine toxoflavin (compound 49) is a PIN1 inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
4.3 μM
Compound: 4j
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay
Antiproliferative activity against human A549 cells assessed as reduction in cell growth measured after 72 hrs by Alamar blue assay
[PMID: 31784197]
HepG2 IC50
1.8 μM
Compound: 4j
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell growth measured after 24 hrs by MTS assay
[PMID: 31784197]
In Vitro

3-Pyridine toxoflavin shows an average (high-throughput screen) HTS potency of 25 μM and 48% inhibition efficacy for PIN1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Pyridine toxoflavin Related Antibodies
Molecular Weight

270.25

Formula

C12H10N6O2
CAS No.
SMILES

O=C(C1=NC(C2=CC=NC=C2)=NN(C)C1=N3)N(C)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3-Pyridine toxoflavin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Pyridine toxoflavin32502-20-8PIN1peptidylprolyl cis/trans isomerase, NIMA-interacting 1proliferative disorderimmune diseaseInhibitorinhibitorinhibit

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3-Pyridine toxoflavin
Cat. No.:
HY-137122
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