(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid

Cat. No.: HY-N8090 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

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(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid, a lanostane triterpenoids, exhibits obvious NO inhibitory activity on n LPS-induced BV-2 microglia cells with an IC₅₀ of 9.55 uM. (3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid has anti-inflammatory activities.

For research use only. We do not sell to patients.

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid Chemical Structure

CAS No. : 1961358-02-0

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1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
BV-2	IC₅₀	9.55 μM Compound: 4	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs measured after 15 mins by Griess assay	[PMID: 27335254]

In Vitro

(3β,7β,12β,20Z)-3,7,12-Trihydroxy-11,15,23-trioxo-lanost-8,20-dien-26-oic acid shows no significant cytotoxicity on BV-2 microglia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

530.65

Formula

C₃₀H₄₂O₈

CAS No.

1961358-02-0

Appearance

Solid

Color

White to off-white

SMILES

C[C@]([C@@]([C@H]1/C(C)=C\C(CC(C)C(O)=O)=O)([C@@H]2O)C)(C(C1)=O)C([C@H](C[C@@]3([H])C4(C)C)O)=C(C2=O)[C@]3(CC[C@@H]4O)C

Structure Classification

Initial Source

Microorganisms

Ganoderma curtisii

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥97.0%

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Data Sheet (272 KB) SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)

References

[1]. Yang Jiao, et al. Lanostane triterpenoids from Ganoderma curtisii and their NO production inhibitory activities of LPS-induced microglia. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3556-61. [Content Brief]