2. Immunology/Inflammation
  3. Macrophage migration inhibitory factor (MIF)
  4. 4-CPPC

4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 µM for MIF-1, MIF-2, respectively.

For research use only. We do not sell to patients.

4-CPPC Chemical Structure

4-CPPC Chemical Structure

CAS No. : 29553-70-6

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

4-CPPC Related Antibodies

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Description

4-CPPC is a potent, reversible and selective MIF-2 inhibitor with Ki values of 431, 33 µM for MIF-1, MIF-2, respectively[1].

IC50 & Target

Ki: 431 µM (MIF-1); 33 µM (MIF-2)[1]
Molecular Weight

287.22

Formula

C14H9NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (348.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4817 mL 17.4083 mL 34.8165 mL
5 mM 0.6963 mL 3.4817 mL 6.9633 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4817 mL 17.4083 mL 34.8165 mL 87.0413 mL
5 mM 0.6963 mL 3.4817 mL 6.9633 mL 17.4083 mL
10 mM 0.3482 mL 1.7408 mL 3.4817 mL 8.7041 mL
15 mM 0.2321 mL 1.1606 mL 2.3211 mL 5.8028 mL
20 mM 0.1741 mL 0.8704 mL 1.7408 mL 4.3521 mL
25 mM 0.1393 mL 0.6963 mL 1.3927 mL 3.4817 mL
30 mM 0.1161 mL 0.5803 mL 1.1606 mL 2.9014 mL
40 mM 0.0870 mL 0.4352 mL 0.8704 mL 2.1760 mL
50 mM 0.0696 mL 0.3482 mL 0.6963 mL 1.7408 mL
60 mM 0.0580 mL 0.2901 mL 0.5803 mL 1.4507 mL
80 mM 0.0435 mL 0.2176 mL 0.4352 mL 1.0880 mL
100 mM 0.0348 mL 0.1741 mL 0.3482 mL 0.8704 mL
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4-CPPC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-CPPC29553-70-6Macrophage migration inhibitory factor (MIF)Inhibitorinhibitorinhibit

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