4-Demethyldeoxypodophyllotoxin

Cat. No.: HY-N10829 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum.

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4-Demethyldeoxypodophyllotoxin Chemical Structure

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1 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4-Demethyldeoxypodophyllotoxin is an aryltetralin lignan that can be found in Podophyllum peltatum^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.8 μM Compound: 3, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 20071056]
A549	IC₅₀	1.8 μM Compound: 13, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22244588]
A549	IC₅₀	1.8 μM Compound: 9, DDPT	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
A549	IC₅₀	3.75 μM Compound: 3, DDPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21733601]
A549	IC₅₀	3.9 μM Compound: DDPT; 6	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HCT-8	IC₅₀	9.81 μM Compound: DDPT; 6	Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HCT8 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HeLa	IC₅₀	0.074 μM Compound: 8	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
HeLa	IC₅₀	43 μM Compound: 9, DDPT	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HeLa	IC₅₀	53.3 μM Compound: 13, DDPT	Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HeLa	IC₅₀	53.3 μM Compound: DDPT; 6	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HeLa	IC₅₀	7.43 μM Compound: 3, DDPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21733601]
HepG2	IC₅₀	16.53 μM Compound: DDPT; 6	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]
HL-60	IC₅₀	0.11 μM Compound: 3, DDPT	Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method Cytotoxicity against human HL60 cells after 72 hrs by CCK8 method	[PMID: 20071056]
HL-60	IC₅₀	2.96 μM Compound: 13, DDPT	Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HL-60	IC₅₀	2.96 μM Compound: 9, DDPT	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
KB	IC₅₀	0.0078 μM Compound: 8	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
RPMI-8226	IC₅₀	0.23 μM Compound: 3, DDPT	Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method Cytotoxicity against human RPMI8226 cells after 72 hrs by CCK8 method	[PMID: 20071056]
SiHa	IC₅₀	2.07 μM Compound: 3, DDPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 21733601]
SiHa	IC₅₀	43 μM Compound: 13, DDPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 22244588]
SiHa	IC₅₀	53.3 μM Compound: 9, DDPT	Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
WI-38	IC₅₀	78.52 μM Compound: DDPT; 6	Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 26873416]

Molecular Weight

384.38

Formula

C₂₁H₂₀O₇

CAS No.

3590-93-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)O)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 99.87%

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Data Sheet (276 KB) SDS (252 KB)

COA (263 KB) HNMR (125 KB) CNMR (115 KB) RP-HPLC (265 KB) MS (466 KB)

Handling Instructions (2659 KB)

References

[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry. 1984, 23 (5): 1147-1152.