4-Hydroxybenzylamine

Name: 4-Hydroxybenzylamine
Brand: MedChemExpress
SKU: HY-W004078
Rating: 4.5 (1 reviews)

Cat. No.: HY-W004078 Purity: 98.50%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Hydroxybenzylamine is an endogenous metabolite.

For research use only. We do not sell to patients.

4-Hydroxybenzylamine Chemical Structure

CAS No. : 696-60-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
1 g	USD 38	In-stock	Estimated Time of Arrival: December 31
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10 g		Get quote

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Biological Activity
Purity & Documentation
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Description

4-Hydroxybenzylamine is an endogenous metabolite.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

123.15

Formula

C₇H₉NO

CAS No.

696-60-6

Appearance

Solid

Color

White to light brown

SMILES

OC1=CC=C(CN)C=C1

Structure Classification

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (812.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.1202 mL	40.6009 mL	81.2018 mL
5 mM	1.6240 mL	8.1202 mL	16.2404 mL
10 mM	0.8120 mL	4.0601 mL	8.1202 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (20.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (20.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (20.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.11%

Select Batch:

Data Sheet (241 KB) SDS (393 KB)

COA (244 KB) HNMR (115 KB) LCMS (275 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.1202 mL	40.6009 mL	81.2018 mL	203.0045 mL
	5 mM	1.6240 mL	8.1202 mL	16.2404 mL	40.6009 mL
	10 mM	0.8120 mL	4.0601 mL	8.1202 mL	20.3004 mL
	15 mM	0.5413 mL	2.7067 mL	5.4135 mL	13.5336 mL
	20 mM	0.4060 mL	2.0300 mL	4.0601 mL	10.1502 mL
	25 mM	0.3248 mL	1.6240 mL	3.2481 mL	8.1202 mL
	30 mM	0.2707 mL	1.3534 mL	2.7067 mL	6.7668 mL
	40 mM	0.2030 mL	1.0150 mL	2.0300 mL	5.0751 mL
	50 mM	0.1624 mL	0.8120 mL	1.6240 mL	4.0601 mL
	60 mM	0.1353 mL	0.6767 mL	1.3534 mL	3.3834 mL
	80 mM	0.1015 mL	0.5075 mL	1.0150 mL	2.5376 mL
	100 mM	0.0812 mL	0.4060 mL	0.8120 mL	2.0300 mL