2. Apoptosis
  3. MDM-2/p53 Bcl-2 Family Apoptosis
  4. 4-Hydroxyresveratrol

4-Hydroxyresveratrol  (Synonyms: 3,4,5,4'-Tetrahydroxystibene)

Cat. No.: HY-126311
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4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA.

For research use only. We do not sell to patients.

4-Hydroxyresveratrol Chemical Structure

4-Hydroxyresveratrol Chemical Structure

CAS No. : 331443-00-6

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4-Hydroxyresveratrol Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol (HY-16561) analog, differentially induces pro-apoptotic p53/Bax gene expression. 4-Hydroxyresveratrol induces apoptosis in SV40 virally transformed WI38 cells (WI38VA) cells, but not in WI38 cells. 4-Hydroxyresveratrol significantly induces the expression of p53, GADD45 and Bax genes and concomitantly suppresses the expression of bcl-2 gene in WI38VA[1].

IC50 & Target[1]

Bax

 

Molecular Weight

244.24

Formula

C14H12O4
CAS No.
SMILES

OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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4-Hydroxyresveratrol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxyresveratrol331443-00-63,4,5,4'-TetrahydroxystibeneMDM-2/p53Bcl-2 FamilyApoptosispro-apoptoticSV40WI38 cellsWI38VAGADD45Baxbcl-2Inhibitorinhibitorinhibit

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