2. NF-κB Autophagy Epigenetics Cell Cycle/DNA Damage Apoptosis Anti-infection
  3. IKK Autophagy Mitophagy Sirtuin Apoptosis Bacterial Fungal Antibiotic Keap1-Nrf2
  4. Resveratrol

Resveratrol  (Synonyms: trans-Resveratrol; SRT501)

Cat. No.: HY-16561 Purity: 99.94%
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Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator. Resveratrol is a potent pregnane X receptor (PXR) inhibitor. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model. Resveratrol increases production of NO in endothelial cells.

For research use only. We do not sell to patients.

Resveratrol Chemical Structure

Resveratrol Chemical Structure

CAS No. : 501-36-0

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10 mM * 1 mL in DMSO
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Customer Review

Based on 109 publication(s) in Google Scholar

Other Forms of Resveratrol:

Resveratrol Related Antibodies

Top Publications Citing Use of Products

93 Publications Citing Use of MCE Resveratrol

WB
IF

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310.  [Abstract]

    Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. The protein expression of SIRT1, SESN2, P-AMPKα, AMPKα and cleaved caspase-3 was detected by western blot analysis with densitometric quantification of each group.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310.  [Abstract]

    Primary cardiomyocytes are transfected with NC-siRNA or Sesn2-siRNA for 24 h, and then treated with DOX (1 μM) in the presence or absence of Resveratrol (RES) (20 μM) for 24 h. Representative images of DHE (red) staining and quantification of the corresponding fluorescence intensity in H9c2 cells.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Redox Biol. 2022 Jun;52:102310.  [Abstract]

    Resveratrol (RES) (10 mg/kg/day; intraperitoneally injected every day for 5 weeks) administration recoveres DOX-reduced expression of SIRT1 in hearts of Sirt1flox/flox mice.

    Resveratrol purchased from MedChemExpress. Usage Cited in: PLoS Biol. 2022 Jun 30;20(6):e3001682.  [Abstract]

    Immunostaining and brightfield of embryos either untreated or treated with solvent or with Resveratrol (1 μM).

    Resveratrol purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2022 Jun;150:113071.

    EX527 antagonizes the protective effect of NRH on Kanamycin-induced hair-cell loss by inhibition of SIRT1, while Resveratrol (RSV; 10 μM) alleviates hair-cell damage caused by EX527.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cells. 2022 Jul 29;11(15):2331.

    The depletion of HSF1 significantly decreased the reactivation efficiencies of Resveratrol.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2021 Nov 29;12(12):1115.  [Abstract]

    Western blot and quantification for MICU3 in C2C12 cells treated with d-gal and Resveratrol (50 μM).

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Prolif. 2021 Mar;54(3):e12991.  [Abstract]

    Representative immunoblots of Ac p53 K381, total p53, progerin, Lamin A/C and Lamin B1 of primary HSECs on Day 2 in four groups (CTR, H2O2, H2O2 + Resveratrol, Resveratrol (1 μM; 2 days)).

    Resveratrol purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240.  [Abstract]

    The expression levels of SIRT3, RUNX2, OCN in BMSCs after indicated treatment are analyzed by western blot.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2021 Nov 20;176:228-240.  [Abstract]

    Representative images of Rhodamine and DHE of treated BMSCs after indicated treatment.

    Resveratrol purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2021 Apr 9;7(4):777-789.  [Abstract]

    Effects of Resveratrol on meningitic E. coli-induced ERK1/2 activation as well as VEGFA upregulation in hBMECs. By pretreatment with Resveratrol, the phosphorylation of ERK1/2 induced by meningitic E. coli in hBMECs is significantly reduced. Similarly, the upregulation of VEGFA also decreased considerably in a dose-dependent manner in resveratrol-treated hBMECs.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251.  [Abstract]

    Resveratrol (50 mg/kg; i.p.; for 2 weeks) has no effect on body weight and kidney index in mice, but it significantly reduces FBG, BUN, and CR.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Feb;42(2):242-251.  [Abstract]

    Western blotting demonstrates that Resveratrol (50 mg/kg; i.p.; for 2 weeks) increases the expression of E-Ca and ZO-1 and decreases the expression of α-SMA, vimentin, snail, and twist.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Aug 28;9(9):847.  [Abstract]

    HIPK2 expression is upregulated by treatments with 5 μM Resveratrol, 30 μM Aspirin, 10 μM Vitamin E, and 15 μM Ursolic acid for another 16 h after the LPS treatment, as analysed by western blotting.

    Resveratrol purchased from MedChemExpress. Usage Cited in: J Agric Food Chem. 2017 Jun 7;65(22):4384-4394.  [Abstract]

    Resveratrol activates the HSF1 signaling pathway. J-Lat A2 cells are treated with various concentrations of Resveratrol or Carfilzomib (50 nM) for 48 h. Then the cells are lysed and Ser320 phosphorylated HSF1 and total HSF1 are detected by Western blot with corresponding antibodies.

    Resveratrol purchased from MedChemExpress. Usage Cited in: Chinese Journal of Cell Biology. 2015, 37(11):1522-1527.

    Effect of Resveratrol on SIRT1 expression in HK-2 cells.

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    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].

    IC50 & Target[1]

    Adenylyl cyclase

    0.8 nM (IC50)

    IKKβ

    1 μM (IC50)

    DNA polymerase α

    3.3 μM (IC50)

    DNA polymerase δ

    5 μM (IC50)

    Autophagy

     

    Mitophagy

     

    Sirtuin

     

    In Vitro

    Resveratrol (trans-Resveratrol; SRT501) is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported[1].
    MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled every 30 hr. Trypan blue exclusion assay shows that at concentrations of 10 μM or lower, Resveratrol does not affect cell viability (90% viable cells) whereas at 100 μM, only 50% of the cells are viable after 6 days of Resveratrol treatment. Moreover, MCF-7 cells do not undergo apoptosis after incubation with Resveratrol at concentration of 10 μM as determined by ApoAlert Annexin V Apoptosis kit[2].
    Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Resveratrol Related Antibodies
    In Vivo

    The average tumor volume is reduced by treatment with Resveratrol (trans-Resveratrol; SRT501) at a dose of 50 mg/kg body weight (195.5±124.8 mm3; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm3; P<0.001) compare with the vehicle-treated animals (315±94 mm3). There is a good correlation between the tumor volume and the tumor mass[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    228.24

    Formula

    C14H12O3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    OC1=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C=C1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (438.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : 50 mg/mL (219.07 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.3814 mL 21.9068 mL 43.8135 mL
    5 mM 0.8763 mL 4.3814 mL 8.7627 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
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    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: 5 mg/mL (21.91 mM); Clear solution; Need ultrasonic

      This protocol yields a clear solution of 5 mg/mL.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

      Solubility: 5 mg/mL (21.91 mM); Clear solution; Need ultrasonic

      This protocol yields a clear solution of 5 mg/mL.

      Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  50% PEG300    50% Saline

      Solubility: 12.5 mg/mL (54.77 mM); Suspended solution; Need ultrasonic

    • Protocol 2

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 16.67 mg/mL (73.04 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.94%

    COA (245 KB) HNMR (247 KB) RP-HPLC (253 KB) LCMS (107 KB) Elemental Analysis Report (103 KB)

    Handling Instructions (2659 KB)
    References
    Cell Assay
    [2]

    To determine the effect of Resveratrol on cell growth, MCF-7 cells are plated in 6-well plates at 105 cells per well in 2 mL of DME-F12 medium supplemented with 5% FBS in the presence or absence of increasing concentrations of Resveratrol. The cell number is measured every 2 days till day 6 with a hemocytometer after detaching the cells with trypsin-EDTA[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Animal Administration
    [3]

    Mice[3]
    Female BALB/c (nu/nu) mice, 6 weeks old, are used. PA-1 cells (1×107 in 200 μL PBS) are injected s.c. on the right hind flank. Tumor volume (length×width×depth×0.52) is measured three times a week. After 10 days of implantation, two groups (n=10) are given Resveratrol (dissolved in 5% ethanol and 25% polyethyleneglycol 400 in distilled water) i.p. at a daily dose of 50 or 100 mg/kg body weight for consecutive 4 weeks, whereas the other group receive the vehicle only. Body weights are recorded everyday. Animals are given bromodeoxyuridine (BrdUrd; 10 mg/kg body weight, i.p.) 2 h before sacrifice. Xenograft tumors are weighed and frozen in liquid nitrogen or fixed in 10% formalin and embedded in paraffin. The BrdUrd-labeled cells in paraffin-embedded tissues are detected employing a monoclonal anti-BrdUrd antibody.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMSO 1 mM 4.3814 mL 21.9068 mL 43.8135 mL 109.5338 mL
    5 mM 0.8763 mL 4.3814 mL 8.7627 mL 21.9068 mL
    10 mM 0.4381 mL 2.1907 mL 4.3814 mL 10.9534 mL
    15 mM 0.2921 mL 1.4605 mL 2.9209 mL 7.3023 mL
    20 mM 0.2191 mL 1.0953 mL 2.1907 mL 5.4767 mL
    25 mM 0.1753 mL 0.8763 mL 1.7525 mL 4.3814 mL
    30 mM 0.1460 mL 0.7302 mL 1.4605 mL 3.6511 mL
    40 mM 0.1095 mL 0.5477 mL 1.0953 mL 2.7383 mL
    50 mM 0.0876 mL 0.4381 mL 0.8763 mL 2.1907 mL
    60 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8256 mL
    80 mM 0.0548 mL 0.2738 mL 0.5477 mL 1.3692 mL
    100 mM 0.0438 mL 0.2191 mL 0.4381 mL 1.0953 mL
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    Resveratrol Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Resveratrol501-36-0trans-Resveratrol SRT501SRT501SRT 501SRT-501IKKAutophagyMitophagySirtuinApoptosisBacterialFungalAntibioticKeap1-Nrf2IκB kinaseI kappa B kinase Mitochondrial AutophagyInhibitorinhibitorinhibit

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