4-Phenylbutyric acid-d₂ (Synonyms: 4-PBA-d₂; Benzenebutyric acid-d₂)

Cat. No.: HY-A0281S3: FAQs
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4-Phenylbutyric acid-d₂ is the deuterium labeled 4-Phenylbutyric acid[1]. 4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

For research use only. We do not sell to patients.

4-Phenylbutyric acid-d<sub>2</sub> Chemical Structure

4-Phenylbutyric acid-d₂ Chemical Structure

CAS No. : 461391-24-2

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1 mg		Get quote	Estimated Time of Arrival: December 31

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Other Forms of 4-Phenylbutyric acid-d₂:

4-Phenylbutyric acid In-stock

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•Related Proteins:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

Biological Activity
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	8.94 mM Compound: PBA	Antiproliferative activity against human A-375 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A-375 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
A549	IC₅₀	9.75 mM Compound: PBA	Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
LNCaP	IC₅₀	2324 μM Compound: 4-PBA	Antiproliferative activity against human LNCAP cells after 24 hrs by MTT assay Antiproliferative activity against human LNCAP cells after 24 hrs by MTT assay	[PMID: 21055848]
MCF7	IC₅₀	10.68 mM Compound: PBA	Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
MDA-MB-231	IC₅₀	11.66 mM Compound: PBA	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by MTT assay	[PMID: 35818137]
PC-3	IC₅₀	2273 μM Compound: 4-PBA	Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay Antiproliferative activity against human PC3 cells after 24 hrs by MTT assay	[PMID: 21055848]

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

168.23

Formula

C₁₀H₈D₄O₂

CAS No.

461391-24-2

Unlabeled CAS

1821-12-1

SMILES

OC(C([2H])([2H])C([2H])([2H])CC1=CC=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]

[2]. Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12. [Content Brief]

[3]. Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15242:24-29. [Content Brief]

[4]. Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May151:9-17. [Content Brief]

4-Phenylbutyric acid-d₂ Related Classifications

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Phenylbutyric acid-d₂461391-24-24-PBA-d₂Benzenebutyric acid-d₂HDACVirus ProteaseHistone deacetylasesInhibitorinhibitorinhibit

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4-Phenylbutyric acid-d2 (Synonyms: 4-PBA-d2; Benzenebutyric acid-d2)

Other Forms of 4-Phenylbutyric acid-d2:

4-Phenylbutyric acid-d2 Related Antibodies