2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. 4-trans-Hydroxy-glibenclamide

4-trans-Hydroxy-glibenclamide  (Synonyms: 4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide)

Cat. No.: HY-117160
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rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.

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4-trans-Hydroxy-glibenclamide Chemical Structure

4-trans-Hydroxy-glibenclamide Chemical Structure

CAS No. : 23155-00-2

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Other Forms of 4-trans-Hydroxy-glibenclamide:

4-trans-Hydroxy-glibenclamide Related Antibodies

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Description

rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.

Molecular Weight

510.00

Formula

C23H28ClN3O6S
CAS No.
SMILES

O=C(NCCC1=CC=C(S(=O)(NC(N[C@H]2CC[C@H](O)CC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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4-trans-Hydroxy-glibenclamide Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-trans-Hydroxy-glibenclamide23155-00-24-trans-hydroxycyclohexyl Glyburide 4-trans-hydroxy GlibenclamidePotassium ChannelKcsAInhibitorinhibitorinhibit

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