2. Cell Cycle/DNA Damage
  3. Antifolate
  4. 5,10-Dideazafolic acid

5,10-Dideazafolic acid is a 5,10-dideaza-5,6,7,8-tetrahydrofola analogue, which exhibits some inhibitory activity against glycine amide ribonucleotide formyltransferase (GARFT) (Ki=13 μM).

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5,10-Dideazafolic acid Chemical Structure

5,10-Dideazafolic acid Chemical Structure

CAS No. : 85597-18-8

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5,10-Dideazafolic acid Related Antibodies

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Description

5,10-Dideazafolic acid is a 5,10-dideaza-5,6,7,8-tetrahydrofola analogue, which exhibits some inhibitory activity against glycine amide ribonucleotide formyltransferase (GARFT) (Ki=13 μM)[1].

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
16.2 nM
Compound: DDATHF
Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using GAR FTase as primary target
Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using GAR FTase as primary target
[PMID: 8035423]
Molecular Weight

439.42

Formula

C21H21N5O6
CAS No.
SMILES

O=C(CC[C@H](NC(C1=CC=C(C=C1)CCC2=CN=C(NC(N)=NC3=O)C3=C2)=O)C(O)=O)O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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5,10-Dideazafolic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,10-Dideazafolic acid85597-18-8AntifolateAnalogsdihydrofolate reductaseinhibitioncancerInhibitorinhibitorinhibit

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