5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione

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5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC₅₀ of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with K_i of 1.9 μM.

For research use only. We do not sell to patients.

5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione Chemical Structure

CAS No. : 333409-31-7

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Description	5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC₅₀ of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with K_i of 1.9 μM^[1]^[2].
Molecular Weight	244.29
Formula	C₇H₈N₄O₂S₂
CAS No.	333409-31-7
SMILES	S=C1OC(CCCC2=NNC(O2)=S)=NN1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (268 KB) Handling Instructions (2659 KB)
References	[1]. Khan KM, et al., 1,3,4-Oxadiazole-2(3H)-thione and its analogues: a new class of non-competitive nucleotide pyrophosphatases/phosphodiesterases 1 inhibitors. Bioorg Med Chem. 2009 Nov 15;17(22):7816-22. [Content Brief] [2]. Ghani U, et al., New potent inhibitors of tyrosinase: novel clues to binding of 1,3,4-thiadiazole-2(3H)-thiones, 1,3,4-oxadiazole-2(3H)-thiones, 4-amino-1,2,4-triazole-5(4H)-thiones, and substituted hydrazides to the dicopper active site. Bioorg Med Chem. 2010 Jun 1;18(11):4042-8. [Content Brief]