2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 5,6,7,8-Tetrahydro-8-deazahomofolic acid

5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase.

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5,6,7,8-Tetrahydro-8-deazahomofolic acid Chemical Structure

5,6,7,8-Tetrahydro-8-deazahomofolic acid Chemical Structure

CAS No. : 111113-75-8

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5,6,7,8-Tetrahydro-8-deazahomofolic acid Related Antibodies

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Description

5,6,7,8-Tetrahydro-8-deazahomofolic acid is a potential thymidylate synthase (TS) inhibitor with inhibitory activity against other folate-related enzymes. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed mild growth inhibition against enterococci, lactic acid bacteria, and L1210 cells in culture. 5,6,7,8-Tetrahydro-8-deazahomofolic acid also showed weak inhibition against thymidylate synthase, dihydrofolate reductase, glycyl-ribonucleoside aminotransferase, and aminoimidazole-carboxyacyl-ribonucleoside aminotransferase. 5,6,7,8-Tetrahydro-8-deazahomofolic acid showed low substrate activity for thymidylate synthase[1].

Molecular Weight

458.47

Formula

C21H26N6O6
CAS No.
SMILES

O=C1C2=C(NC(N)=N1)CC[C@@H](N2)CCNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5,6,7,8-Tetrahydro-8-deazahomofolic acid Related Classifications

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Keywords:

5,6,7,8-Tetrahydro-8-deazahomofolic acid111113-75-8DNA/RNA SynthesisInhibitorinhibitorinhibit

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