2. Anti-infection
  3. Parasite
  4. 5,7,8-Trimethoxycoumarin

5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.

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5,7,8-Trimethoxycoumarin Chemical Structure

5,7,8-Trimethoxycoumarin Chemical Structure

CAS No. : 60796-65-8

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5,7,8-Trimethoxycoumarin Related Antibodies

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Description

5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively[1].

IC50 & Target

Trypanosoma

 

Cellular Effect
Cell Line Type Value Description References
U-937 CC50
> 2 mM
Compound: BA-8
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
[PMID: 19716307]
U-937 IC50
> 400 μM
Compound: BA-8
Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting
Growth inhibition of human U937 cells assessed as [3H]5-methyl thymidine incorporation after 48 hrs by liquid scintillation counting
[PMID: 19716307]
In Vitro

5,7,8-Trimethoxycoumarin (0-100 μM; 72 h) inhibits the proliferation of Trypanosoma cruzi and L. amazonensis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5,7,8-Trimethoxycoumarin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Trypanosoma cruzi (epimastigotes) and L. amazonensis (promastigote)
Concentration: 1.5, 3.1, 6.2, 12.5, 25, 50 and 100 μM
Incubation Time: 72 h
Result: Inhibited the proliferation in a dose-dependent manner with IC50s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively.
Molecular Weight

236.22

Formula

C12H12O5
CAS No.
SMILES

O=C1C=CC2=C(OC)C=C(OC)C(OC)=C2O1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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5,7,8-Trimethoxycoumarin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5,7,8-Trimethoxycoumarin60796-65-8ParasiteTrypanosoma cruziantiparasitic activityInhibitorinhibitorinhibit

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