2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. 5-Aza-7-deazaguanine

5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides.

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5-Aza-7-deazaguanine Chemical Structure

5-Aza-7-deazaguanine Chemical Structure

CAS No. : 67410-64-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 143 In-stock
Solution
10 mM * 1 mL in Water USD 143 In-stock
Solid
5 mg USD 130 In-stock
10 mg USD 220 In-stock
25 mg USD 450 In-stock
50 mg USD 750 In-stock
100 mg USD 1250 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

5-Aza-7-deazaguanine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 5-Aza-7-deazaguanine

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  • Purity & Documentation

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Description

5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides[1].

IC50 & Target

Purine nucleoside phosphorylase, Nucleoside Antimetabolite/Analog[1]
Molecular Weight

151.13

Formula

C5H5N5O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N=C(N)N=C2N1C=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (33.08 mM; ultrasonic and adjust pH to 9 with NaOH)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6168 mL 33.0841 mL 66.1682 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.6168 mL 33.0841 mL 66.1682 mL 165.4205 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL 33.0841 mL
10 mM 0.6617 mL 3.3084 mL 6.6168 mL 16.5420 mL
15 mM 0.4411 mL 2.2056 mL 4.4112 mL 11.0280 mL
20 mM 0.3308 mL 1.6542 mL 3.3084 mL 8.2710 mL
25 mM 0.2647 mL 1.3234 mL 2.6467 mL 6.6168 mL
30 mM 0.2206 mL 1.1028 mL 2.2056 mL 5.5140 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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5-Aza-7-deazaguanine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Aza-7-deazaguanine67410-64-4Nucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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