5-FAM-LL-37 TFA 

5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy^[1].

4851.56 (free acid)

C₂₂₆H₃₅₀N₆₀O₅₉.xC₂HF₃O₂

Solid

Light yellow to yellow

{Fluorescein-5-carbonyl}-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser

{Fluorescein-5-carbonyl}-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES

OC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]1N(CCC1)C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC(C2=CC3=C(C=C2)C4(OC3=O)C5=C(C=C(C=C5)O)OC6=C4C=CC(O)=C6)=O)CC(C)C)=O)CC(C)C)=O)=O)CC(O)=O)=O)CC7=CC=CC=C7)=O)CC8=CC=CC=C8)=O)CCCNC(N)=N)=O)CCCCN)=O)CO)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)[C@H](CC)C)=O)=O)CCCCN)=O)CCC(O)=O)=O)CC9=CC=CC=C9)=O)CCCCN)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)C(C)C)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CCCCN)=O)CC(O)=O)=O)CC%10=CC=CC=C%10)=O)CC(C)C)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(C)C)=O)C(C)C)=O)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CCC(O)=O)=O)C(O)=O.OC(C(F)(F)F)=O.[x]

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Pastuszak K, et al., Insight into the Mechanism of Interactions between the LL-37 Peptide and Model Membranes of Legionella gormanii Bacteria. Int J Mol Sci. 2023 Jul 27;24(15):12039.  [Content Brief]