2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT1AR agonist 1

5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC50 value of 34 nM, SERT reuptake ihibitor (IC50 =12 nM), NET reuptake inhibitor (IC50 =78 nM) and DAT reuptake inhibitor (IC50 =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs.

For research use only. We do not sell to patients.

5-HT1AR agonist 1 Chemical Structure

5-HT1AR agonist 1 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

5-HT1AR agonist 1 Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

5-HT1AR agonist 1 (Compound A3) emerges as a relatively balanced multi-target activity profile, including 5-HT1AR agonist with an EC50 value of 34 nM, SERT reuptake ihibitor (IC50 =12 nM), NET reuptake inhibitor (IC50 =78 nM) and DAT reuptake inhibitor (IC50 =135 nM). 5-HT1AR agonist 1 performs significant antidepressant effects and exhibits excellent bioavailability and low clearance in mice, which is promising for research in the field of antidepressant drugs[1].
IC50 & Target[1]

SERT

12 nM (IC50)

NET

78 nM (IC50)

DAT

135 nM (IC50)

In Vivo

5-HT1AR agonist 1 (2.5 MG/ KG, I.V. and 10 MG / KG, P.O.) shows excellent oral bioavailability and low clearance in mice[1].
5-HT1AR agonist 1 (30 MG/KG, i.p., 30 min) shows the robust antidepressant potential in the forced swimming test in mice, similar to the effect of Vilazodone (HY-14262)[1]
In Vivo pharmacokinetic parameters of 5-HT1AR agonist 1 in ICR mice.[1]

药代动力学分析[1]

Route Dose (mg/kg) Tmax (h) Cmax (ng/mL) AUClast (ng·h/mL) T1/2 (h) CL (mL/min/kg) Vd (L/kg) F (%)
A3 PO. 2.07 ± 0.15 0.42 ± 0.08 4980 ± 1590 16913 ± 2451 / / 147 %
10 mg/kg
IV. 2.64 ± 0.50 0.08 ± 0.00 2633 ± 104 2842 ± 142 14.62 ± 0.78 3.38 ± 0.79
10 mg/kg

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice
Dosage: 2.5 MG/ KG, I.V. and 10 MG / KG, P.O.
Administration: I.V. and P.O., a single dose
Result: Showed excellent oral bioavailability in mice[1]
Animal Model: C57 mice
Dosage: 30 MG/KG
Administration: i.p., a single dose
Result: Significantly reduced immobility time in the forced swimming test in mice, similar to the effect of Vilazodone (HY-14262)[1]
Molecular Weight

418.49

Formula

C24H26N4O3
SMILES

NC(C1=CC2=C(O1)C=CC(N3CCN(CCC4=CC=C(CCC(N5)=O)C5=C4)CC3)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

5-HT1AR agonist 1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-HT1AR agonist 15-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1AR agonismSERT reuptake ihibitionNET reuptake inhibitionDAT reuptake inhibitionantidepressant effectsdepressant deseaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
5-HT1AR agonist 1
Cat. No.:
HY-162585
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.