5-Hydroxyindole-3-acetic acid-d₆

Name: 5-Hydroxyindole-3-acetic acid-d 6
Brand: MedChemExpress
SKU: HY-W008253S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-W008253S1 Purity: 99.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

5-Hydroxyindole-3-acetic acid-d₆ is the deuterium labeled 5-Hydroxyindole-3-acetic acid. 5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.

For research use only. We do not sell to patients.

5-Hydroxyindole-3-acetic acid-d<sub>6</sub> Chemical Structure

5-Hydroxyindole-3-acetic acid-d₆ Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote
10 mg	Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 5-Hydroxyindole-3-acetic acid-d₆:

5-Hydroxyindole-3-acetic acid In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

197.22

Formula

C₁₀H₃D₆NO₃

Unlabeled CAS

54-16-0

Appearance

Solid

Color

White to off-white

SMILES

OC1=C([2H])C(C(C([2H])([2H])C(O)=O)=C([2H])N2)=C2C([2H])=C1[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

Ethanol : 50 mg/mL (253.52 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0705 mL	25.3524 mL	50.7048 mL
5 mM	1.0141 mL	5.0705 mL	10.1410 mL
10 mM	0.5070 mL	2.5352 mL	5.0705 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (255 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Corcuff JB, et al. Urinary sampling for 5HIAA and metanephrines determination: revisiting the recommendations. Endocr Connect. 2017 Aug;6(6):R87-R98. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	5.0705 mL	25.3524 mL	50.7048 mL	126.7620 mL
	5 mM	1.0141 mL	5.0705 mL	10.1410 mL	25.3524 mL
	10 mM	0.5070 mL	2.5352 mL	5.0705 mL	12.6762 mL
	15 mM	0.3380 mL	1.6902 mL	3.3803 mL	8.4508 mL
	20 mM	0.2535 mL	1.2676 mL	2.5352 mL	6.3381 mL
	25 mM	0.2028 mL	1.0141 mL	2.0282 mL	5.0705 mL
	30 mM	0.1690 mL	0.8451 mL	1.6902 mL	4.2254 mL
	40 mM	0.1268 mL	0.6338 mL	1.2676 mL	3.1690 mL
	50 mM	0.1014 mL	0.5070 mL	1.0141 mL	2.5352 mL
	60 mM	0.0845 mL	0.4225 mL	0.8451 mL	2.1127 mL
	80 mM	0.0634 mL	0.3169 mL	0.6338 mL	1.5845 mL
	100 mM	0.0507 mL	0.2535 mL	0.5070 mL	1.2676 mL