5-LOX-IN-6 

5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of 5-lipoxygenase (5-LO). 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC₅₀ values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research^[1].

5-LOX-IN-6 (compound 11a) (0-10 µM) efficiently blocks 5-LO product formation in human whole blood assays (IC₅₀=0.83-1.6 µM)^[1].
5-LOX-IN-6 (0-10 µM) fails to block A23187 (HY-N6687, 2.5 µM)-induced translocation of 5-LO in neutrophils^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

5-LOX-IN-6 (compound 11a) (4 mg/kg, ip) significantly prevents leukotriene B₄ production in pleural exudates of λ-carrageenan (HY-N9470)-treated rats, associated with reduced severity of pleurisy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

379.84

C₂₂H₁₈ClNO₃

1159576-98-3

O=C(C1=C(CC2=CC(Cl)=CC=C2)NC3=C1C=C(C4=C3C=CC=C4)O)OCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Karg EM, et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52(11):3474-83.  [Content Brief]