5-Methylresorcinol monohydrate (Synonyms: Orcinol monohydrate)

Cat. No.: HY-W015715 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

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5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent.

For research use only. We do not sell to patients.

5-Methylresorcinol monohydrate Chemical Structure

CAS No. : 6153-39-5

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Description

In Vitro

5-Methylresorcinol monohydrate (Orcinol monohydrate) (100, 200, 500 µM; 24, 72 h) shows cytotoxicity for B16, Hs68 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	B16, Hs68 cells
Concentration:	100, 200, 500 µM
Incubation Time:	24, 72 h
Result:	Showed cytotoxicity with the inhibition rate of 101.7% for Hs68 cells at 24 h and 104.4% inhibition rate for B16 cells at 72 h.

In Vivo

5-Methylresorcinol monohydrate (2.5, 5 mg/kg; p.o.) shows anxiolytic activity without sedative effects ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	18-22 g Male CD-1 mice^[2]
Dosage:	2.5, 5 mg/kg
Administration:	P.o.
Result:	Increased the time spent in open arms and the number of entries into open arms in the elevated plus-maze test, increased the number of head-dips in the hole-board test; did not significantly affect the locomotion of mice in the open-field test.

Molecular Weight

142.15

Formula

C₇H₁₀O₃

CAS No.

6153-39-5

Appearance

Solid

SMILES

OC1=CC(C)=CC(O)=C1.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥95.0%

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Data Sheet (270 KB) SDS (393 KB)

COA (247 KB) HNMR (130 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Chen YH, et al. Skin whitening capability of shikimic acid pathway compound. Eur Rev Med Pharmacol Sci. 2016;20(6):1214-20. [Content Brief]

[2]. Wang X, et al. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm Biol. 2015 Jun;53(6):876-81. [Content Brief]

5-Methylresorcinol monohydrate Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Methylresorcinol6153-39-5OrcinolTyrosinaseB16Hs68 cellsoral activecross the blood-brain barrieranxiolyticInhibitorinhibitorinhibit

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