5-Methylresorcinol monohydrate (Synonyms: Orcinol monohydrate)

Cat. No.: HY-W015715 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

5-Methylresorcinol monohydrate (Orcinol monohydrate) is a tyrosinase inhibitor. 5-Methylresorcinol monohydrate shows cytotoxicity. 5-Methylresorcinol monohydrate also is an oral active and cross the blood-brain barrier anxiolytic agent.

For research use only. We do not sell to patients.

5-Methylresorcinol monohydrate Chemical Structure

CAS No. : 6153-39-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	Get quote	Estimated Time of Arrival: December 31
10 g	Get quote	Estimated Time of Arrival: December 31
50 g	Get quote

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Description

In Vitro

5-Methylresorcinol monohydrate (Orcinol monohydrate) (100, 200, 500 µM; 24, 72 h) shows cytotoxicity for B16, Hs68 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	B16, Hs68 cells
Concentration:	100, 200, 500 µM
Incubation Time:	24, 72 h
Result:	Showed cytotoxicity with the inhibition rate of 101.7% for Hs68 cells at 24 h and 104.4% inhibition rate for B16 cells at 72 h.

In Vivo

5-Methylresorcinol monohydrate (2.5, 5 mg/kg; p.o.) shows anxiolytic activity without sedative effects ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	18-22 g Male CD-1 mice^[2]
Dosage:	2.5, 5 mg/kg
Administration:	P.o.
Result:	Increased the time spent in open arms and the number of entries into open arms in the elevated plus-maze test, increased the number of head-dips in the hole-board test; did not significantly affect the locomotion of mice in the open-field test.

Molecular Weight

142.15

Formula

C₇H₁₀O₃

CAS No.

6153-39-5

Appearance

Solid

SMILES

OC1=CC(C)=CC(O)=C1.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (703.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0348 mL	35.1741 mL	70.3482 mL
5 mM	1.4070 mL	7.0348 mL	14.0696 mL
10 mM	0.7035 mL	3.5174 mL	7.0348 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (17.59 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (247 KB) HNMR (130 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Chen YH, et al. Skin whitening capability of shikimic acid pathway compound. Eur Rev Med Pharmacol Sci. 2016;20(6):1214-20. [Content Brief]

[2]. Wang X, et al. Anxiolytic effects of orcinol glucoside and orcinol monohydrate in mice. Pharm Biol. 2015 Jun;53(6):876-81. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.0348 mL	35.1741 mL	70.3482 mL	175.8706 mL
	5 mM	1.4070 mL	7.0348 mL	14.0696 mL	35.1741 mL
	10 mM	0.7035 mL	3.5174 mL	7.0348 mL	17.5871 mL
	15 mM	0.4690 mL	2.3449 mL	4.6899 mL	11.7247 mL
	20 mM	0.3517 mL	1.7587 mL	3.5174 mL	8.7935 mL
	25 mM	0.2814 mL	1.4070 mL	2.8139 mL	7.0348 mL
	30 mM	0.2345 mL	1.1725 mL	2.3449 mL	5.8624 mL
	40 mM	0.1759 mL	0.8794 mL	1.7587 mL	4.3968 mL
	50 mM	0.1407 mL	0.7035 mL	1.4070 mL	3.5174 mL
	60 mM	0.1172 mL	0.5862 mL	1.1725 mL	2.9312 mL
	80 mM	0.0879 mL	0.4397 mL	0.8794 mL	2.1984 mL
	100 mM	0.0703 mL	0.3517 mL	0.7035 mL	1.7587 mL

5-Methylresorcinol monohydrate Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Methylresorcinol6153-39-5OrcinolTyrosinaseB16Hs68 cellsoral activecross the blood-brain barrieranxiolyticInhibitorinhibitorinhibit

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5-Methylresorcinol monohydrate (Synonyms: Orcinol monohydrate)

5-Methylresorcinol monohydrate Related Antibodies

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•Related Small Molecules:

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5-Methylresorcinol monohydrate Related Antibodies

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