5HT6-ligand-2

Cat. No.: HY-162636: FAQs
Data Sheet Handling Instructions

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5HT6-ligand-2 (compound 15) is a potent 5-HT₆ inhibitor with K_i values of 3.4, 15 nM for 5-HT6, SERT, respectively. 5HT6-ligand-2 shows neuroprotection. 5HT6-ligand-2 has the potential for the research of dementia.

For research use only. We do not sell to patients.

5HT6-ligand-2 Chemical Structure

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

5-HT₆ Receptor

In Vivo

BET-IN-26 (compound 13a) (10, 100 mg/kg; p.o.) decreases the LPS (HY-D1056) induced serum levels of IL-6 and MCP-1 in a dose-dependent manner in mice^[1].
Pharmacokinetic Parameters (2.5 mg/kg; i.p.; Male Wistar rats)^[1].

Parameter	Serum	Brain
C_max (ng/ml(g))	45.21	3.78
t_max (min)	30	30
l_z (min^-1)	0.0099	0.0072
t_0.5 (min)	70.08	96.71
V_z/F (l/kg)	55.87	-
CL/F (l/min/kg)	0.55	-
AUC_(0-inf) (ng/mL*min)	4542.15	606.48
MRT (min)	104.27	152.35

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	230-260 g, 8 weeks old Male Wistar rats (MK-801-induced memory impairment)^[1]
Dosage:	2.5, 5, 7.5 mg/kg
Administration:	I.p.; 30 min before testing
Result:	Significantly reduced immobility time by 30.5 % and increased climbing behaviors by 63 %, without affecting the duration of swimming at 5 mg/kg.

Molecular Weight

476.57

Formula

C₂₉H₂₈N₆O

SMILES

O=C1N(CC2=CC=CC=C2)C3=CC=CC(N(CC4)CCN4CCC5=CNC6=C5C=C(C#N)C=C6)=C3N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Siwek A, et al. Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties. Eur J Med Chem. 2024 Sep 5;275:116601. [Content Brief]

5HT6-ligand-2 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5HT6-ligand-25-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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