2. NF-κB
  3. IKK
  4. 6-Chloro-7-deazaguanine

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively.

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6-Chloro-7-deazaguanine Chemical Structure

6-Chloro-7-deazaguanine Chemical Structure

CAS No. : 84955-31-7

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6-Chloro-7-deazaguanine Related Antibodies

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Description

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively[1].

Molecular Weight

168.58

Formula

C6H5ClN4
CAS No.
Appearance

Solid

SMILES

NC1=NC(Cl)=C2C(NC=C2)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: 99.72%

COA (250 KB) HNMR (130 KB) RP-HPLC (272 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
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6-Chloro-7-deazaguanine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Chloro-7-deazaguanine84955-31-7IKKIκB kinaseI kappa B kinaseInhibitorinhibitorinhibit

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