2. Induced Disease Models Products Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Immunology and Inflammatory Disease Models Apoptosis Reactive Oxygen Species Xanthine Oxidase
  4. Hapten
  5. 6-Formylpterin

6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells.

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6-Formylpterin Chemical Structure

6-Formylpterin Chemical Structure

CAS No. : 712-30-1

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1 mg USD 35 In-stock
5 mg USD 70 In-stock
10 mg USD 115 In-stock
25 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

6-Formylpterin Related Antibodies

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Description

6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells[1].

In Vitro

6-Formylpterin (2 mM) generats intracellular ROS in HL-60 cells[1].
6-Formylpterin (0.5, 1, and 2 mM, 3 h) increases intracellular H2O2, which induces apoptosis in HL-60 cells and Jurkat cells [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Formylpterin Related Antibodies

Apoptosis Analysis[1]

Cell Line: HL-60 cells, Jurkat cells
Concentration: 0.5, 1, and 2 mM
Incubation Time: 3 h
Result: Induced apoptosis in HL-60 cells[1].
Inhibited Fas-mediated apoptosis in Jurkat cells in 0.5 mM[1].
Molecular Weight

191.15

Formula

C7H5N5O2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=CC1=CN=C2N=C(N)NC(C2=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (174.37 mM; ultrasonic and adjust pH to 12 with 1 M NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2315 mL 26.1575 mL 52.3149 mL
5 mM 1.0463 mL 5.2315 mL 10.4630 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (247 KB) HNMR (217 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.2315 mL 26.1575 mL 52.3149 mL 130.7873 mL
5 mM 1.0463 mL 5.2315 mL 10.4630 mL 26.1575 mL
10 mM 0.5231 mL 2.6157 mL 5.2315 mL 13.0787 mL
15 mM 0.3488 mL 1.7438 mL 3.4877 mL 8.7192 mL
20 mM 0.2616 mL 1.3079 mL 2.6157 mL 6.5394 mL
25 mM 0.2093 mL 1.0463 mL 2.0926 mL 5.2315 mL
30 mM 0.1744 mL 0.8719 mL 1.7438 mL 4.3596 mL
40 mM 0.1308 mL 0.6539 mL 1.3079 mL 3.2697 mL
50 mM 0.1046 mL 0.5231 mL 1.0463 mL 2.6157 mL
60 mM 0.0872 mL 0.4360 mL 0.8719 mL 2.1798 mL
80 mM 0.0654 mL 0.3270 mL 0.6539 mL 1.6348 mL
100 mM 0.0523 mL 0.2616 mL 0.5231 mL 1.3079 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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6-Formylpterin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Formylpterin712-30-1ApoptosisReactive Oxygen SpeciesXanthine OxidaseXOCell proliferationHL-60PanC-1Inhibitorinhibitorinhibit

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