2. Neuronal Signaling GPCR/G Protein PI3K/Akt/mTOR Stem Cell/Wnt
  3. Melanocortin Receptor GSK-3
  4. 6-Methoxy-4-methylcoumarin

6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo.

For research use only. We do not sell to patients.

6-Methoxy-4-methylcoumarin Chemical Structure

6-Methoxy-4-methylcoumarin Chemical Structure

CAS No. : 6295-35-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

6-Methoxy-4-methylcoumarin Related Antibodies

Top Publications Citing Use of Products

View All Melanocortin Receptor Isoform Specific Products:

View All Isoforms
MC1R MC3R MC2R MC4R MC5R

View All GSK-3 Isoform Specific Products:

View All Isoforms
GSK-3 GSK-3α GSK-3β

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo[1].

In Vitro

6-Methoxy-4-methylcoumarin (25-400 μM; 72 hours) demonstrates a survival rate of 67.95% at 200 μM and 90.38% at 100 μM. 6-Methoxy-4-methylcoumarin significantly stimulates melanin production in a concentration-dependent manner at 25, 50, and 100 μM. 6-Methoxy-4-methylcoumarin enhances tyrosinase activity in B16F10 cells, subsequently stimulating melanin production[1].
6-Methoxy-4-methylcoumarin (25-100 μM; 4 hours) inhibits ERK and AKT phosphorylation, which leads to the upregulation of MITF and TRP proteins. 6-Methoxy-4-methylcoumarin activates GSK3β phosphorylation, reduces β-catenin phosphorylation, and stimulates melanogenesis via the GSK3β/β-catenin pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6-Methoxy-4-methylcoumarin Related Antibodies

Cell Viability Assay[1]

Cell Line: B16F10 melanoma cells
Concentration: 25 μM, 50 μM, 100 μM, 200 μM, 400 μM
Incubation Time: 72 hours
Result: Demonstrated a survival rate of 67.95% at 200 μM and 90.38% at 100 μM.

Western Blot Analysis[1]

Cell Line: B16F10 melanoma cells
Concentration: 25 μM, 50 μM, 100 μM
Incubation Time: 4 hours
Result: Decreased AKT and ERK phosphorylation.
Molecular Weight

190.20

Formula

C11H10O3
CAS No.
SMILES

CC1=CC(=O)OC2=C1C=C(C=C2)OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

6-Methoxy-4-methylcoumarin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Methoxy-4-methylcoumarin6295-35-8Melanocortin ReceptorGSK-3MC ReceptorGlycogen synthase kinase-3Glycogen synthase kinase 3VitiligoERKAKTmelanin synthesisGSK3β/β-catenin pathwayInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
6-Methoxy-4-methylcoumarin
Cat. No.:
HY-W267446
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.