2. Immunology/Inflammation
  3. NO Synthase
  4. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one 

Cat. No.: HY-N0997
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(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one (compound7) is a nature product isolated from rhizomes of Curcuma kwangsiensis. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one has inhibitory effect on NO production induced by LPS in macrophages with an IC50 value of 8.93 μM.

For research use only. We do not sell to patients.

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one Chemical Structure

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one Chemical Structure

CAS No. : 1251830-57-5

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(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one Related Antibodies

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Description

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one (compound7) is a nature product isolated from rhizomes of Curcuma kwangsiensis. (6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one has inhibitory effect on NO production induced by LPS in macrophages with an IC50 value of 8.93 μM[1].

Cellular Effect
Cell Line Type Value Description References
B16-4A5 IC50
1.24 μM
Compound: 5
Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of theophylline-induced melanin production after 72 hrs by spectrophotometry relative to control
Antimelanogenic activity in mouse B16-4A5 cells assessed as inhibition of theophylline-induced melanin production after 72 hrs by spectrophotometry relative to control
[PMID: 23910596]
RAW264.7 IC50
8.93 μM
Compound: 7
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production by MTT assay
[PMID: 20879743]
Molecular Weight

296.36

Formula

C19H20O3
CAS No.
SMILES

O=C(CC/C=C/C1=CC=C(O)C=C1)CCC2=CC=C(O)C=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one1251830-57-5NO SynthaseNitric oxide synthasesNOSCurcuma kwangsiensisAnticancerAnti-inflammatoryLPSMacrophagesInhibitorinhibitorinhibit

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