1. Natural Products
  2. Plants Flavonoids
  3. Leguminosae Flavones
  4. Sophora japonica (L.) Schott
  5. 7,3'-Di-O-Methylorobol

7,3'-Di-O-Methylorobol is a flavone that can be isolated from Sophora japonica.

For research use only. We do not sell to patients.

7,3'-Di-O-Methylorobol Chemical Structure

7,3'-Di-O-Methylorobol Chemical Structure

CAS No. : 104668-88-4

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Based on 1 publication(s) in Google Scholar

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Description

7,3'-Di-O-Methylorobol is a flavone that can be isolated from Sophora japonica[1].

Cellular Effect
Cell Line Type Value Description References
C2C12 IC50
32.47 μg/mL
Compound: 16
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
[PMID: 33412152]
Neutrophil IC50
> 10 μM
Compound: 4
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation pretreated for 5 mins followed by cytochalasin B addition for 3 mins and subsequent fMLP stimulation for 10 mins by superoxide dismutase
[PMID: 29381070]
Neutrophil IC50
> 10 μM
Compound: 4
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pretreated for 5 mins followed by fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as substrate
[PMID: 29381070]
RBL-2H3 IC50
> 100 μM
Compound: 4
Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release pretreated for 10 mins followed by DNP-BSA addition measured after 10 mins by p-NAG substrate based assay
Antiallergic activity in anti-DNP IgE-sensitized rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta hexosaminidase release pretreated for 10 mins followed by DNP-BSA addition measured after 10 mins by p-NAG substrate based assay
[PMID: 29381070]
Molecular Weight

314.29

Formula

C17H14O6

CAS No.
SMILES

O=C1C(C2=CC=C(O)C(OC)=C2)=COC3=CC(OC)=CC(O)=C13

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
7,3'-Di-O-Methylorobol
Cat. No.:
HY-N7806
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