7-Deacetylgedunin

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7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro.

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7-Deacetylgedunin Chemical Structure

CAS No. : 10314-90-6

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 20 μM Compound: 17	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
AZ-521 cell line	IC₅₀	16.9 μM Compound: 17	Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
HepG2	IC₅₀	10.26 μM Compound: 12	Cytotoxicity against human HepG2 cells after 3 days by MTT assay Cytotoxicity against human HepG2 cells after 3 days by MTT assay	[PMID: 19908853]
HL-60	IC₅₀	> 20 μM Compound: 17	Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
Huh-7	CC₅₀	105 μM Compound: 9	Cytotoxicity against human HuH7 cells after 72 hrs by MTS assay Cytotoxicity against human HuH7 cells after 72 hrs by MTS assay	[PMID: 25330401]
Huh-7	EC₅₀	12.5 μM Compound: 9	Antiviral activity against dengue virus 2 infected in human HuH7 cells after 72 hrs by Western blot and ECL detection based assay Antiviral activity against dengue virus 2 infected in human HuH7 cells after 72 hrs by Western blot and ECL detection based assay	[PMID: 25330401]
MCF7	IC₅₀	28.96 μM Compound: 2	Antiproliferative activity against human MCF7 cells after 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs	[PMID: 18816111]
RAW264.7	IC₅₀	< 10 μM Compound: 7	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite level after 24 hrs by Griess method Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite level after 24 hrs by Griess method	[PMID: 21733687]
RAW264.7	IC₅₀	37.58 μM Compound: 7	Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 21733687]
RAW264.7	IC₅₀	9.191 μM Compound: B; DAG	Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay	[PMID: 35427124]
SK-BR-3	IC₅₀	12 μM Compound: 17	Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
SK-BR-3	IC₅₀	21.09 μM Compound: 2	Antiproliferative activity against human SKBr3 cells after 72 hrs Antiproliferative activity against human SKBr3 cells after 72 hrs	[PMID: 18816111]

Molecular Weight

440.53

Formula

C₂₆H₃₂O₆

CAS No.

10314-90-6

SMILES

C[C@]12[C@]34[C@]([C@H](C5=COC=C5)OC([C@@]3([H])O4)=O)(CC[C@]1([H])[C@@]6([C@@](C(C)(C(C=C6)=O)C)([H])C[C@H]2O)C)C

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chen JY, et al. 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling. Oncotarget. 2017 Jul 5;8(33):55051-55063. [Content Brief]