2. Academic Validation
  3. Limonoids from seeds of Thai Xylocarpus moluccensis

Limonoids from seeds of Thai Xylocarpus moluccensis

  • Bioorg Med Chem Lett. 2011 Aug 1;21(15):4485-9. doi: 10.1016/j.bmcl.2011.06.010.
Warin Ravangpai 1,  Damrong Sommit,  Thapong Teerawatananond,  Nuntawan Sinpranee,  Tanapat Palaga,  Somchai Pengpreecha,  Nongnuj Muangsin,  Khanitha Pudhom
Affiliations

Affiliation

  • 1 Research Centre of Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
PMID: 21733687 DOI: 10.1016/j.bmcl.2011.06.010
Abstract

A new andirobin, thaimoluccensin A (1), and two new phragmalin-type limonoids, thaimoluccensins B (2) and C (3), were isolated from seeds of a Thai mangrove plant, Xylocarpus moluccensis, together with eight known compounds. The structures of these compounds were elucidated on the basis of spectroscopic data. Only 7-deacetylgedunin (7), a gedunin-type limonoid, exhibited significant inhibitory activity against nitric oxide production from activated macrophages with IC(50) value less than 10 μM, suggesting that the compound has anti-inflammatory activity.

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