2. Epigenetics TGF-beta/Smad
  3. PKC
  4. 7-Oxostaurosporine

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.

For research use only. We do not sell to patients.

7-Oxostaurosporine Chemical Structure

7-Oxostaurosporine Chemical Structure

CAS No. : 125035-83-8

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Customer Review

Based on 1 publication(s) in Google Scholar

7-Oxostaurosporine Related Antibodies

Top Publications Citing Use of Products

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

  • Biological Activity

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Description

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.78 μM
Compound: 15
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
ASPC1 IC50
1.2 μM
Compound: 15
Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
BXPC-3 IC50
0.43 μM
Compound: 15
Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
MGC-803 IC50
1.52 μM
Compound: 15
Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
NCI-H1299 IC50
2.03 μM
Compound: 15
Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
NCI-H1975 IC50
2.01 μM
Compound: 15
Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
PC-9 IC50
1.88 μM
Compound: 15
Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
RKO IC50
1.47 μM
Compound: 15
Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
[PMID: 33100009]
In Vitro

7-Oxostaurosporine (50 nM, 24 h) can lead to an increase in plasma membrane sphingomyelin in CHO cells but does not alter ceramide content[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Oxostaurosporine Related Antibodies
In Vivo

7-Oxostaurosporine (6 mg/kg, once daily, intravenous) significantly reduces tumour growth with a tumour growth inhibition (TGI) of 56.1% and no significant effect on body weigh[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

480.51

Formula

C28H24N4O4
CAS No.
SMILES

[H][C@@]12N3C4=C(C5=C(C6=C4C7=C3C=CC=C7)C(NC6=O)=O)N(C8=C5C=CC=C8)[C@](C)([C@@H]([C@@H](C2)NC)OC)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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7-Oxostaurosporine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Oxostaurosporine125035-83-8PKCProtein kinase CapoptosisNF-κBp65tumorInhibitorinhibitorinhibit

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