2. Epigenetics TGF-beta/Smad
  3. PKC
  4. 7-Oxostaurosporine

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.

For research use only. We do not sell to patients.

7-Oxostaurosporine Chemical Structure

7-Oxostaurosporine Chemical Structure

CAS No. : 125035-83-8

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Based on 1 publication(s) in Google Scholar

7-Oxostaurosporine Related Antibodies

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PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKC-ι ℩ PKCι

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Description

7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway[1][2].

In Vitro

7-Oxostaurosporine (50 nM, 24 h) can lead to an increase in plasma membrane sphingomyelin in CHO cells but does not alter ceramide content[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-Oxostaurosporine Related Antibodies
In Vivo

7-Oxostaurosporine (6 mg/kg, once daily, intravenous) significantly reduces tumour growth with a tumour growth inhibition (TGI) of 56.1% and no significant effect on body weigh[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

480.51

Formula

C28H24N4O4
CAS No.
SMILES

[H][C@@]12N3C4=C(C5=C(C6=C4C7=C3C=CC=C7)C(NC6=O)=O)N(C8=C5C=CC=C8)[C@](C)([C@@H]([C@@H](C2)NC)OC)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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7-Oxostaurosporine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Oxostaurosporine125035-83-8PKCProtein kinase CapoptosisNF-κBp65tumorInhibitorinhibitorinhibit

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