2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 8-Isoprostaglandin F2α

8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

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8-Isoprostaglandin F2α Chemical Structure

8-Isoprostaglandin F2α Chemical Structure

CAS No. : 27415-26-5

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Based on 1 publication(s) in Google Scholar

Other Forms of 8-Isoprostaglandin F2α:

8-Isoprostaglandin F2α Related Antibodies

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Description

8-Isoprostaglandin F2α is an isoprostane produced by the non-enzymatic peroxidation of arachidonic acid in membrane phospholipids. 8-Isoprostaglandin F2α is present in human plasma in two distinct forms - esterified in phospholipids and as the free acid. 8-Isoprostaglandin F2α is a weak TP receptor agonist in vascular smooth muscle.

IC50 & Target

Human Endogenous Metabolite

 

Molecular Weight

354.48

Formula

C20H34O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCC[C@H](O)/C=C/[C@@H]1[C@@H]([C@@H](O)C[C@H]1O)C/C=C\CCCC(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (282.10 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8210 mL 14.1052 mL 28.2103 mL
5 mM 0.5642 mL 2.8210 mL 5.6421 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8210 mL 14.1052 mL 28.2103 mL 70.5258 mL
5 mM 0.5642 mL 2.8210 mL 5.6421 mL 14.1052 mL
10 mM 0.2821 mL 1.4105 mL 2.8210 mL 7.0526 mL
15 mM 0.1881 mL 0.9403 mL 1.8807 mL 4.7017 mL
20 mM 0.1411 mL 0.7053 mL 1.4105 mL 3.5263 mL
25 mM 0.1128 mL 0.5642 mL 1.1284 mL 2.8210 mL
30 mM 0.0940 mL 0.4702 mL 0.9403 mL 2.3509 mL
40 mM 0.0705 mL 0.3526 mL 0.7053 mL 1.7631 mL
50 mM 0.0564 mL 0.2821 mL 0.5642 mL 1.4105 mL
60 mM 0.0470 mL 0.2351 mL 0.4702 mL 1.1754 mL
80 mM 0.0353 mL 0.1763 mL 0.3526 mL 0.8816 mL
100 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7053 mL
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8-Isoprostaglandin F2α Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Isoprostaglandin F2α27415-26-5Endogenous MetaboliteInhibitorinhibitorinhibit

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