2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. 8-Br-7-CH-ADPR

8-Br-7-CH-ADPR  (Synonyms: 8-Bromo-7-deazaadenosine-5'-O-diphosphoribose)

Cat. No.: HY-134268
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8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes.

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8-Br-7-CH-ADPR Chemical Structure

8-Br-7-CH-ADPR Chemical Structure

CAS No. : 1011457-95-6

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8-Br-7-CH-ADPR Related Antibodies

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Description

8-Br-7-CH-ADPR (8-Bromo-7-deazaadenosine-5'-O-diphosphoribose) is a specific TRPM2 antagonist that inhibits TRPM2 activation by binding to the NUDT9 homology domain of the TRPM2 channel, thereby controlling the influx of cations through the cell membrane channel. 8-Br-7-CH-ADPR can be used to study the role of TRPM2 in pathological processes such as cell death, neurodegenerative diseases, myocardial infarction, and diabetes[1].

Molecular Weight

637.22

Formula

C16H23BrN4O14P2
CAS No.
SMILES

O[C@H]1[C@@H](O)[C@H](N(C(Br)=C2)C3=C2C(N)=NC=N3)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)C(O)O4)(O)=O)(O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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8-Br-7-CH-ADPR Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-Br-7-CH-ADPR1011457-95-68-Bromo-7-deazaadenosine-5'-O-diphosphoriboseTRP ChannelTransient receptor potential channelsAntagonistsCation channelsNeurodegenerative diseasesMyocardial infarctionTRPM2Inhibitorinhibitorinhibit

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