8-epi-Chlorajapolide F

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8-epi-Chlorajapolide F (compound 1) a sesquiterpene that can be isolated from the aboveground part of the Chloranthus japonicus. 8-epi-Chlorajapolide has few cytotoxic to human cancer cell lines NCI-H460 and SMMC-7721 (IC₅₀s>50 μg/mL).

For research use only. We do not sell to patients.

8-epi-Chlorajapolide F Chemical Structure

CAS No. : 863301-69-3

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	> 50 μM Compound: 5	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins followed by LPS stimulation for 24 hrs by Griess assay	[PMID: 27588583]

Molecular Weight

276.33

Formula

C₁₆H₂₀O₄

CAS No.

863301-69-3

SMILES

C=C1[C@H]2C[C@H]2[C@@]3([C@@H]([C@]4(OC(C(C)=C4C[C@@H]13)=O)OC)O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang M, et al. Sesquiterpenes from the aerial part of Chloranthus japonicus and their cytotoxicities. Fitoterapia. 2012 Dec;83(8):1604-9. [Content Brief]