8-OAc

Cat. No.: HY-162515: FAQs
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8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines.

For research use only. We do not sell to patients.

8-OAc Chemical Structure

CAS No. : 2550395-87-2

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Description

8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines^[1].

In Vitro

8-OAc (5-100 μM; 24 h) could preferentially target cancer cells for the initiation of cell death pathways, while having minimal effects on viability of non-cancer cells. 8-OAc can induce ROS production, leading to cell death in liver cancer cells^[1].
8-OAc is able to achieve a mitohormetic effect in C. elegans and prolong longevity in adult worms. 8-OAc requires HSF1 mediate heat shock response (HSR) pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Huh-7 liver carcinoma cells and BJ fibroblast non-cancer cells
Concentration:	5 μM, 10 μM, 50 μM, 100 μM
Incubation Time:	24 h
Result:	Inhibited Huh-7 and BJ cells with IC50 of 95.97 μM and 248.15 μM, respectively.

Molecular Weight

446.60

Formula

C₂₄H₃₄N₂O₄S

CAS No.

2550395-87-2

SMILES

O=C(NCCC(/C=C\C[C@H](OC(C)=O)C(C)(C)C1=NC(C/C=C\CC=C)=CS1)=C)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Naibedya Dutta, et al. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Apr 3. [Content Brief]

8-OAc Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8-OAc2550395-87-2Mitochondrial Metabolismmitochondrial functionagingETC complex IHSF1Inhibitorinhibitorinhibit

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