8MDP

Cat. No.: HY-110104 Purity: 97.9%: FAQs
Data Sheet SDS COA Handling Instructions

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8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC₅₀ of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H³] uridine by K562 cells and K15NTD cells.

For research use only. We do not sell to patients.

8MDP Chemical Structure

CAS No. : 29491-75-6

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5 mg	USD 325	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
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Description

8MDP is a potent equilibrative nucleoside transporter 1 (ENT1) inhibitor with an IC₅₀ of 0.43 nM. 8MDP inhibits hENT1 and hENT2 uptake of [H³] uridine by K562 cells and K15NTD cells^[1]^[2].

IC₅₀ & Target

Equilibrative Nucleoside Transporter 1 (ENT1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	8.67 nM Compound: 13	Inhibition of ENT1 in human K562 cells by flow cytometric assay Inhibition of ENT1 in human K562 cells by flow cytometric assay	[PMID: 17636949]

Molecular Weight

560.73

Formula

C₂₈H₄₈N₈O₄

CAS No.

29491-75-6

Appearance

Solid

Color

Light yellow to green yellow

SMILES

OCCN(CCO)C1=NC(N2CCCCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCCCC4)C3=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 97.9%

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Data Sheet (275 KB) SDS (251 KB)

COA (259 KB) Elemental Analysis Report (117 KB)

Handling Instructions (2659 KB)

References

[1]. Lin W, et al. Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe. Bioconjug Chem. 2011 Jun 15;22(6):1221-7. [Content Brief]

[2]. Lin W, et al. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J Med Chem. 2007 Aug 9;50(16):3906-20. [Content Brief]

8MDP Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8MDP29491-75-6OthersENT1K562K15NTDInhibitorinhibitorinhibit

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