2. Metabolic Enzyme/Protease Neuronal Signaling
  3. Monoamine Oxidase Cytochrome P450
  4. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 

Cat. No.: HY-134664
Handling Instructions

Molarity Calculator

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively.

For research use only. We do not sell to patients.

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Chemical Structure

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Chemical Structure

CAS No. : 67667-71-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Related Antibodies

Top Publications Citing Use of Products

View All Monoamine Oxidase Isoform Specific Products:

View All Isoforms
MAO-A MAO-B

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC50s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits MAO-A and MAO-B with IC50s of 60.2 and 38.6 μM, respectively[1].

IC50 & Target

IC50: 8.64 μM (CYP2A6, pre-incubation), 22.3 μM (CYP2A6, co-incubation), 38.6 μM (MAO-B), 60.2 μM(MAO-A)[1]
Ki: 15.1 μM (CYP2A6), 27.2 μM (MAO-B), 60.2 μM (MAO-A)[1]
Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
5.2 μM
Compound: 5
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
Inhibition of TNFalpha-induced NF-kappaB activity expressed in human HEK 293 cells after 6 hrs by luciferase reporter gene assay
[PMID: 22850207]
MCF7 IC50
7.7 μM
Compound: 7
Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay
Antiproliferative activity against human MCF7 cells for 72 hrs by cyquant assay
[PMID: 26331426]
MDA-MB-231 IC50
5.2 μM
Compound: 7
Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay
Antiproliferative activity against human MDA-MB-231 cells for 72 hrs by cyquant assay
[PMID: 26331426]
NIH3T3 IC50
7.1 μM
Compound: 7
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells
Cytotoxicity against mouse NIH/3T3 cells after 72 hrs by cyquant cells
[PMID: 26331426]
RAW264.7 IC50
6.6 μM
Compound: 5
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
Antiinflammatory activity against LPS-induced NO production in mouse RAW264.7 cells assessed as reduction in nitrite level preincubated for 15 mins prior to LPS treatment by Griess method
[PMID: 22850207]
SF-295 IC50
9.1 μM
Compound: 7
Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay
Antiproliferative activity against human SF295 cells for 72 hrs by cyquant assay
[PMID: 26331426]
U-251 IC50
2.6 μM
Compound: 7
Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay
Antiproliferative activity against human U251MG cells for 72 hrs by cyquant assay
[PMID: 26331426]
U-373MG ATCC IC50
8.3 μM
Compound: 7
Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay
Antiproliferative activity against human U373MG cells for 72 hrs by cyquant assay
[PMID: 26331426]
Molecular Weight

406.43

Formula

C21H26O8
CAS No.
SMILES

CC(OCC1=C([C@H](C[C@H]2C)OC(C(C)=C)=O)/C(OC1=O)=C\[C@](O[C@]23O)(CC3)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate67667-71-4Monoamine OxidaseCytochrome P450MAOCYPsP4502A6CYP2A6Vernonia cinereaasthmabronchitisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate
Cat. No.:
HY-134664
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (0 KB) Français - FR (0 KB) Deutsch - DE (0 KB) Norwegian - NO (0 KB) Español - ES (0 KB) Swedish - SV (0 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.