Cytochrome P450 Inhibitors

CYP1

CYP2

CYP3

CYP4

CYP11

CYP17

Aromatase/CYP19A1

CYP26

CYP51

CYP2D6

CYP2C9

CYP2C19

CYP3A4

CYP17A1

Cytochrome P450 Inducers, Degraders, Inhibitors, Activators & Modulators

Product Name	CYP1	CYP2	CYP3	CYP4	CYP11	CYP17	Aromatase/CYP19A1	CYP26	CYP51	CYP2D6	CYP2C9	CYP2C19	CYP3A4	CYP17A1	Purity
Verapamil			CYP3												99.96%
Fenofibrate		CYP2C19, IC₅₀: 0.2 μM CYP2B6, IC₅₀: 0.7 μM CYP2C9, IC₅₀: 9.7 μM CYP2C8, IC₅₀: 4.8 μM	CYP3A4, IC₅₀: 142.1 μM												99.93%
Apigenin		CYP2													99.58%
Verapamil hydrochloride			CYP3												99.98%
Aminoglutethimide							Aromatase								98.79%
Letrozole							Aromatase								99.95%
1-Aminobenzotriazole		CYP2	CYP3												99.88%
Ketoconazole			CYP3	CYP4											99.64%
Abiraterone acetate						CYP17									99.96%
Clarithromycin			CYP3												99.90%
Cepharanthine		CYP2E1, IC₅₀: 25.62 μM CYP2C9, IC₅₀: 24.57 μM	CYP3A4, IC₅₀: 16.29 μM												99.91%
Gemfibrozil 1-O-β-glucuronide		CYP2C8, IC₅₀: 4.07 μM													99.88%
Diosmetin	CYP1														99.63%
Fomepizole		CYP2E1													99.67%
Salvianolic acid C		CYP2C8, Ki: 4.82 μM CYP2J2, Ki: 5.75 μM													99.94%
Stiripentol		CYP2	CYP3												99.96%
Talarozole								CYP26							99.61%
HET0016				CYP4											99.69%
(S)-Mephenytoin		CYP2													99.85%
Anastrozole							Aromatase								99.99%
Sulfaphenazole		CYP2C9													99.83%
Gemfibrozil	CYP1A2, Ki: 82 μM	CYP2C9, Ki: 5.8 μM CYP2C19, Ki: 24 μM CYP2C8, Ki: 69 μM													99.91%
Troleandomycin			CYP3												≥98.0%
Exemestane							Aromatase								99.92%
Cobicistat			CYP3												99.77%
Clobetasol propionate			CYP3A5, IC₅₀: 0.206 μM CYP3A4, IC₅₀: 15.6 μM												99.85%
Oleuropein							Aromatase								99.05%
Galangin	CYP1														99.96%
Isavuconazole			CYP3												99.99%
Bergamottin	CYP1A1, Ki: 10.703 nM CYP1A1, IC₅₀: 0.192 μM CYP1A2, IC₅₀: 5.077 μM	CYP2B2, IC₅₀: 4.535 μM CYP2B1, IC₅₀: 9.495 μM													99.80%
Pregnenolone 16α-carbonitrile		CYP2	CYP3												98.48%
Clopidogrel hydrogen sulfate		CYP2B6, IC₅₀: 18.2 nM CYP2C19, IC₅₀: 524 nM													99.43%
Alpha-Naphthoflavone							Aromatase								98.54%
TMS	CYP1B1, IC₅₀: 6 nM CYP1A1, IC₅₀: 300 nM CYP1A2, IC₅₀: 3.1 μM CYP1B1, Ki: 3 nM														98.61%
Ginsenoside Rd	CYP1A2, IC₅₀: 78.4 μM	CYP2D6, IC₅₀: 58 μM CYP2C9, IC₅₀: 85.1 μM	CYP3A4, IC₅₀: 81.7 μM												99.88%
K777			CYP3												99.77%
Schisandrin A			CYP3A, IC₅₀: 6.6 μM												99.89%
Ginsenoside C-K		CYP2C9, IC₅₀: 32 μM CYP2A6, IC₅₀: 63.6 μM													99.92%
Olivetol		CYP2													99.81%
AS1810722			CYP3A4												98.14%
Gentiopicroside		CYP2													99.59%
Atazanavir sulfate			CYP3												99.94%
BMS-986202		CYP2C19, IC₅₀: 14 μM													99.92%
Rhapontigenin	CYP1A1, IC₅₀: 400 nM														99.66%
Phillyrin	CYP1	CYP2													98.99%
Endoxifen hydrochloride							Aromatase								98.75%
Topiroxostat			CYP3												99.63%
7-Ethoxyresorufin	CYP1														99.61%
Clomethiazole		CYP2													99.75%
Mephenytoin		CYP2													99.96%
Schisandrol B		CYP2	CYP3A												99.99%
5,7-Dimethoxyflavone			CYP3A												99.86%
Galeterone						CYP17									99.87%
Tetrahydrocurcumin		CYP2C9	CYP3A4												99.43%
Ranitidine hydrochloride		CYP2													99.88%
Chlorzoxazone		CYP2													99.84%
Atazanavir			CYP3												99.86%
Bergaptol			CYP3												99.44%
Curcumenol			CYP3												99.69%
Oteseconazole											CYP2C9, IC₅₀: 99 μM	CYP2C19, IC₅₀: 72 μM			99.56%
Dihydromethysticin			CYP3												99.94%
Tebuconazole									CYP51						99.66%
Fadrozole							Aromatase								99.78%
CYP3cide			CYP3A4, EC₅₀: 30 nM CYP3A5, EC₅₀: 17 μM CYP3A7, EC₅₀: 71 μM												99.46%
Fadrozole hydrochloride							Aromatase								99.34%
Cecropin B			CYP3												99.00%
APD668		CYP2C9, Ki: 0.1 μM													99.10%
Oxiconazole nitrate			CYP3A4												≥98.0%
Isosilybin			CYP3												99.95%
Casopitant mesylate			CYP3A4												99.84%
Cedrol		CYP2	CYP3												≥98.0%
LKY-047		CYP2J2, IC₅₀: 1.7 μM													98.85%
Endoxifen							Aromatase								99.42%
Ginsenoside F1		CYP2	CYP3A4												≥99.0%
Ticlopidine		CYP2	CYP3												99.34%
Cephaeline dihydrochloride		CYP2													99.84%
Harmalol hydrochloride	CYP1														99.72%
Fipronil	CYP1	CYP2	CYP3												98.98%
β-Apo-8'-carotenal	CYP1A1 CYP1A2
AZD7325	CYP1A2		CYP3A4												99.27%
Seviteronel						CYP17									99.83%
Mefentrifluconazole									CYP51A, Kd: 0.5 nM						99.61%
Obtusifoliol									CYP51						99.86%
AMG-208			CYP3A4, IC₅₀: 32 μM												99.86%
TP0472993				CYP4A11, IC₅₀: 140 nM CYP4F2, IC₅₀: 40 nM											98.69%
Ezutromid	CYP1														98.10%
DMU2105	CYP1B1, IC₅₀: 10 nM CYP1A1, IC₅₀: 742 nM														99.54%
Tetrahydropiperine	CYP1A1, IC₅₀: 23 μM														99.41%
Friedelin		CYP2	CYP3												≥99.0%
2-Phenyl-2-(1-piperidinyl)propane	CYP1A2, IC₅₀: >300 μM	CYP2B6, IC₅₀: 5.1 μM CYP2B6, Ki: 5.6 μM CYP2D6, IC₅₀: 74 μM CYP2A6, IC₅₀: >300 μM CYP2C8, IC₅₀: >300 μM CYP2C9, EC₅₀: >300 μM CYP2C19, IC₅₀: >300 μM CYP2E1, IC₅₀: >300 μM	CYP3A, IC₅₀: 200 μM												99.81%
2,6-Dimethylquinoline	CYP1A2, IC₅₀: 3.3 μM	CYP2B6, IC₅₀: 480 μM													99.95%
Carbosulfan	CYP1	CYP2	CYP3												≥98.0%
Dagrocorat		CYP2D6	CYP3A												99.90%
Dapaconazole								CYP26, IC₅₀: 1.4 μM							99.76%
Dihydrolanosterol									CYP51						99.56%
NN1177 TFA													CYP3A4		98.66%
MS-PPOH		CYP2													99.27%
Flavanone							Aromatase								99.84%
PC945									CYP51A, IC₅₀: 0.23 μM CYP51B, IC₅₀: 0.22 μM						99.27%
Quilseconazole									CYP51						98.98%
Liarozole								CYP26, IC₅₀: 7 μM							98.83%
Nicotelline								CYP26, Ki: ≥300 μM							99.92%
Fenofibrate (Standard)		CYP2B6 CYP2C19 CYP2C8 CYP2C9	CYP3A4												99.91%
6',7'-Dihydroxybergamottin			CYP3A4												≥99.0%
ACP-5862		CYP2C8	CYP3A4												98.41%
Orteronel						CYP17									99.70%
BI 689648					CYP11										99.20%
Nonsteroidal aromatase inhibitor 1							Aromatase								98.88%
Linderane		CYP2													99.61%
Antihistamine-1		CYP2D6, IC₅₀: 5.4 μM													99.45%
Liarozole dihydrochloride								CYP26, IC₅₀: 7 μM							≥99.0%
BI 653048	CYP1A2, IC₅₀: 50 μM	CYP2D6, IC₅₀: 41 μM CYP2C9, IC₅₀: 12 μM CYP2C19, IC₅₀: 9 μM	CYP3A4, IC₅₀: 8 μM												99.84%
DMU2139	CYP1B1, IC₅₀: 9 nM CYP1A1, IC₅₀: 795 nM														≥98.0%
Nampt-IN-5			CYP3, IC₅₀: 0.7 nM												98.02%
Phortress	CYP1														99.25%
Pradefovir mesylate			CYP3												99.89%
Abiraterone acetate (Standard)						CYP17									99.85%
8-Geranyloxypsoralen			CYP3												99.93%
SDZ285428									CYP51						98.00%
Dagrocorat hydrochloride		CYP2D6	CYP3A												99.85%
CYP1B1-IN-4	CYP1B1, IC₅₀: 0.2 nM CYP1A1, IC₅₀: 3.98 μM														99.09%
Chrysosplenetin			CYP3A												99.75%
Polygalaxanthone III		CYP2													99.76%
Ranitidine		CYP2C19 CYP2C9
SR9186			CYP3												98.06%
ONT-993		CYP2D6, IC₅₀: 7.9 μM													99.85%
Letrozole-d₄							Aromatase								99.82%
α-Terpinyl acetate		CYP2B6, Kd: 5.4  μM
ML252	CYP1A2, IC₅₀: 6.1 μM	CYP2C9, IC₅₀: 18.9 μM CYP2D6, IC₅₀: 19.9 μM	CYP3A4, IC₅₀: 3.9 μM												99.9%
hCYP3A4 Fluorogenic substrate 1			CYP3A4, Km: 0.36 μM												99.27%
N-Nornuciferine		CYP2													99.82%
MCH-1 antagonist 1			CYP3A4, IC₅₀: 10 μM
(R)-(+)-Aminoglutethimide							Aromatase
Exemestane (Standard)							Aromatase								99.63%
1'-Hydroxy bufuralol		CYP2
Eriodictyol chalcone							Aromatase
ε-Viniferin	CYP1A2, Ki: 5 μM ((EROD))	CYP2B6, Ki: 3 μM ((BROD)) CYP2A6, Ki: 60 μM ((COH)) CYP2E1, IC₅₀: 25 μM ((CHZ))	CYP3A4, Ki: 10 μM ((TST))	CYP4A, IC₅₀: 15 μM ((LwOH))											≥98.0%
Gemfibrozil (Standard)	CYP1A2	CYP2C19 CYP2C8 CYP2C9													99.90%
CYP11B2-IN-1					CYP11B2, IC₅₀: 2.3 nM CYP11B1, IC₅₀: 142 nM										99.83%
Revexepride			CYP3A4												99.84%
1-(Isothiazol-3-yl)ethan-1-one		CYP2E1
Resorufin methyl ether	CYP1														99.75%
Chlorzoxazone (Standard)		CYP2													99.81%
Seviteronel (R enantiomer)						CYP17									98.82%
4,5-Dimethoxycanthin-6-one	CYP1A2, IC₅₀: 1.7 μM CYP1A2, Ki: 2.6 μM														98.68%
Vorozole							Aromatase
Abiraterone decanoate						CYP17
IHMT-PI3Kδ-372		CYP2C9, IC₅₀: 2.7 μM
Fomepizole hydrochloride		CYP2E1
BMS-819881			CYP3A4, EC₅₀: 13 μM
BMS-986339		CYP2C8, IC₅₀: 8 μM CYP2C9, IC₅₀: 13.5 μM
Fadrozole hydrochloride hemihydrate							Aromatase
Anastrozole-d₁₂							Aromatase
Endoxifen-d₅							Aromatase
CYP3A4-IN-2			CYP3A4, IC₅₀: 0.055 μM
CYP11B1-IN-2	CYP1A2, IC₅₀: >10 μM	CYP2C9, IC₅₀: >10 μM CYP2C19, IC₅₀: >10 μM CYP2D6, IC₅₀: >10 μM CYP2E1, IC₅₀: >10 μM	CYP3A4, IC₅₀: >10 μM		CYP11B1, IC₅₀: 9 ± 2 nM (human CYP11B1) CYP11B1, IC₅₀: 25 nM (rat CYP11B1) CYP11B2, IC₅₀: 1121 ± 237 nM
Antitumor agent-88	CYP1A1, Ki: 1.4 μM
17-HETE	CYP1B1
SYN20028567							Aromatase
P-gp inhibitor 23													CYP3A4
CYP4Z1-IN-1		CYP2D6, IC₅₀: >10 000 nM CYP2C9, IC₅₀: >10 000 nM	CYP3A4, IC₅₀: >10 000 nM	CYP4Z1, IC₅₀: 41.8 ± 1.4 nM CYP4F11, IC₅₀: 291.3 ± 46 nM CYP4F12, IC₅₀: 1598.3 ± 5 nM
CYP3A4-IN-3			CYP3A4, IC₅₀: 0.075 μM
Diosmetin (Standard)	CYP1
CYP1B1-IN-2	CYP1B1, IC₅₀: 0.52 nM CYP1A1, IC₅₀: 16.7 nM CYP1A2, IC₅₀: 94.2 nM
ERα degrader 9							Aromatase
CYP17-IN-1						CYP17
CYP1B1-IN-5	CYP1B1, IC₅₀: 4.7 nM CYP1A1, IC₅₀: 190.7 nM CYP1A2, IC₅₀: 585.7 nM
FGFR-IN-10		CYP2C9, IC₅₀: 3.33 μM CYP2C19, IC₅₀: 18.75 μM CYP2D6, IC₅₀: 4.34 μM	CYP3A4, IC₅₀: 0.69 μM
CYP17A1/HDAC6-IN-1														CYP17A1, IC₅₀: 0.284 μM
hCYP1B1-IN-2	CYP1B1, IC₅₀: 0.040 nM CYP1A1, IC₅₀: 0.38 nM
Antiproliferative agent-53-d₃		CYP2C19, IC₅₀: 0.77 μM CYP2C9, IC₅₀: 3.1 μM CYP2D6, IC₅₀: 17.3 μM	CYP3A4, IC₅₀: 14.6 μM
HIV-1 inhibitor-40		CYP2C9, IC₅₀: 5.16 μM CYP2C19, IC₅₀: 4.51 μM
BChE-IN-33		CYP2C19 CYP2C9 CYP2D6
ASN-001														CYP17A1
Anticancer agent 78							Aromatase
CYP3A4-IN-1			CYP3A4, IC₅₀: 0.085 μM
CYP51/HDAC-IN-1									CYP51
Exemestane-¹³C₃							Aromatase
Kushenol K			CYP3A4, Ki: 1.35 μM
PROTAC ERα Degrader-9							Aromatase, IC₅₀: 4.6 μM
CYP1B1-IN-3	CYP1B1, IC₅₀: 6.6 nM CYP1A1, IC₅₀: 347.3 nM CYP1A2, IC₅₀: >10000 nM
Antitumor agent-87	CYP1A1, Ki: 0.23 μM
DL-Acetylshikonin	CYP1A2, IC₅₀: 4.0 μM	CYP2A6, IC₅₀: 3.8 μM CYP2B6, IC₅₀: 2.0 μM CYP2C8, IC₅₀: 1.4 μM CYP2C9, IC₅₀: 3.3 μM CYP2C19, IC₅₀: 2.5 μM CYP2D6, IC₅₀: 2.5 μM CYP2E1, IC₅₀: 2.7 μM CYP2J2, IC₅₀: 3.3 μM	CYP3A, IC₅₀: 2.3 μM
Exemestane-d₂							Aromatase
5,7,2',6'-Tetrahydroxyflavone			CYP3A4, IC₅₀: 7.8 μM
IDO1-IN-19		CYP2C9, IC₅₀: 8.64 μM													98.52%
7-Ethoxy-4-methylcoumarin	CYP1A1	CYP2B6 CYP2B4													99.44%
Aromatase-IN-3							Aromatase, IC₅₀: 54 nM
YM511							Aromatase								99.73%
BI 653048 phosphate	CYP1A2, IC₅₀: 50 μM	CYP2D6, IC₅₀: 41 μM CYP2C9, IC₅₀: 12 μM CYP2C19, IC₅₀: 9 μM	CYP3A4, IC₅₀: 8 μM
Exemestane-d₃							Aromatase
Apigenin (Standard)		CYP2
CFG920					CYP11B2	CYP17
Nav1.7-IN-8		CYP2C9, IC₅₀: 0.17 μM	CYP3A4, IC₅₀: 0.077 μM
Galangin (Standard)	CYP1
JNK-IN-14										CYP2D6, IC₅₀: 26.7 ± 0.5 nM			CYP3A4, IC₅₀: 383.0 ± 1. nM
Bucolome		CYP2													98.93%
Fenofibrate-d₆		CYP2	CYP3												99.70%
Oxiconazole			CYP3A4
Tetrahydrocurcumin-d₆		CYP2	CYP3
Antibacterial agent 132							Aromatase
CYP4A11/CYP4F2-IN-1				CYP4A11, IC₅₀: 19 nM CYP4F2, IC₅₀: 17 nM											99.82%
Androsta-1,4,6-triene-3,17-dione							Aromatase
7-Hydroxyflavanone							Aromatase
Phortress free base	CYP1
PROTAC CYP1B1 degrader-2	CYP1B1, DC₅₀: 1 nM
Tabimorelin			CYP3A4
hCYP3A4-IN-1			CYP3A4, IC₅₀: 43.93 nM
Monoamine oxidase/Aromatase-IN-1							Aromatase
RO6889678			CYP3A4
CYP51/PD-L1-IN-4									CYP51, IC₅₀: 0.17 ± 0.0 μM
Azamulin			CYP3A, IC₅₀: 0.03-0.24 μM
Tabimorelin hemifumarate			CYP3A4
Aromatase-IN-2							Aromatase								99.83%
17(S)-HETE	CYP1B1
Licopyranocoumarin			CYP3A4, IC₅₀: 32 μM
Methysticin	CYP1A1
CYP11B2-IN-2					CYP11B2, IC₅₀: 0.3 nM CYP11B1, IC₅₀: 3.8 nM
Isolimonexic acid							Aromatase
CYP1B1 ligand 3	CYP1B1, IC₅₀: 11.9 nM CYP1A1, IC₅₀: 278.7 nM CYP1A2, IC₅₀: 3913.5 nM
CYP3A4-IN-4			CYP3A4
Cloperidone											CYP2C9, IC₅₀: 17.7 μM
ML252 hydrochloride	CYP1A2, IC₅₀: 6.1 μM	CYP2C9, IC₅₀: 18.9 μM CYP2D6, IC₅₀: 19.9 μM	CYP3A4, IC₅₀: 3.9 μM
Sorafenib N-oxide													CYP3A4, Ki: 15 μM
Org30958							Aromatase

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