2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 9AzNue5Ac

9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

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9AzNue5Ac Chemical Structure

9AzNue5Ac Chemical Structure

CAS No. : 76487-51-9

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Description

9AzNue5Ac, 9-azido-9-deoxy-N-acetylneuraminic acid, is a click chemistry reagent and a Neu5Ac analogue with the substitution of 9-hydroxyl group with an azide. 9AzNue5Ac could be metabolized and incorporated into sialoglycans in living cells and mice. Click chemistry has great potential for use in binding between nucleic acids, lipids, proteins, and other molecules, and has been used in many research fields because of its beneficial characteristics, including high yield, high specificity, and simplicity[1]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Molecular Weight

334.28

Formula

C11H18N4O8
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

[N-]=[N+]=NC[C@@H](O)[C@@H](O)[C@H](O)[C@H](NC(C)=O)[C@@H](O)CC(C(O)=O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 62.5 mg/mL (186.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9915 mL 14.9575 mL 29.9150 mL
5 mM 0.5983 mL 2.9915 mL 5.9830 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.9915 mL 14.9575 mL 29.9150 mL 74.7876 mL
5 mM 0.5983 mL 2.9915 mL 5.9830 mL 14.9575 mL
10 mM 0.2992 mL 1.4958 mL 2.9915 mL 7.4788 mL
15 mM 0.1994 mL 0.9972 mL 1.9943 mL 4.9858 mL
20 mM 0.1496 mL 0.7479 mL 1.4958 mL 3.7394 mL
25 mM 0.1197 mL 0.5983 mL 1.1966 mL 2.9915 mL
30 mM 0.0997 mL 0.4986 mL 0.9972 mL 2.4929 mL
40 mM 0.0748 mL 0.3739 mL 0.7479 mL 1.8697 mL
50 mM 0.0598 mL 0.2992 mL 0.5983 mL 1.4958 mL
60 mM 0.0499 mL 0.2493 mL 0.4986 mL 1.2465 mL
80 mM 0.0374 mL 0.1870 mL 0.3739 mL 0.9348 mL
100 mM 0.0299 mL 0.1496 mL 0.2992 mL 0.7479 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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9AzNue5Ac Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

9AzNue5Ac76487-51-9Endogenous Metaboliteclick chemistryhigh yieldhigh specificitysimplicitybindingsialoglycansacetylneuraminic acidInhibitorinhibitorinhibit

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