2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Acamprosate calcium

Acamprosate calcium  (Synonyms: Calcium N-acetylhomotaurinate)

Cat. No.: HY-17030 Purity: ≥98.0%
SDS COA Handling Instructions

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Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.

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Acamprosate calcium Chemical Structure

Acamprosate calcium Chemical Structure

CAS No. : 77337-73-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 55 In-stock
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10 mM * 1 mL in Water USD 55 In-stock
Solid
50 mg USD 50 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Acamprosate calcium:

Acamprosate calcium Related Antibodies

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Description

Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. IC50 value: Target: GABA receptor Acamprosate, or N-acetyl homotaurine, is an N-methyl-D-aspartate receptor modulator approved by the Food and Drug Administration (FDA) as a pharmacological treatment for alcohol dependence.Acamprosate has low bioavailability, but also has an excellent tolerability and safety profile. In comparison with naltrexone and disulfiram, which are the other FDA-approved treatments for alcohol dependence, acamprosate is unique in that it is not metabolized by the liver and is also not impacted by alcohol use, so can be administered to patients with hepatitis or liver disease (a common comorbid condition among individuals with alcohol dependence) and to patients who continue drinking alcohol.

Clinical Trial
Molecular Weight

200.24

Formula

C5H10NO4S.1/2Ca
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(NCCCS([O-])(=O)=O)=O.[0.5Ca2+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (499.40 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9940 mL 24.9700 mL 49.9401 mL
5 mM 0.9988 mL 4.9940 mL 9.9880 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (249 KB) HNMR (158 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9940 mL 24.9700 mL 49.9401 mL 124.8502 mL
5 mM 0.9988 mL 4.9940 mL 9.9880 mL 24.9700 mL
10 mM 0.4994 mL 2.4970 mL 4.9940 mL 12.4850 mL
15 mM 0.3329 mL 1.6647 mL 3.3293 mL 8.3233 mL
20 mM 0.2497 mL 1.2485 mL 2.4970 mL 6.2425 mL
25 mM 0.1998 mL 0.9988 mL 1.9976 mL 4.9940 mL
30 mM 0.1665 mL 0.8323 mL 1.6647 mL 4.1617 mL
40 mM 0.1249 mL 0.6243 mL 1.2485 mL 3.1213 mL
50 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4970 mL
60 mM 0.0832 mL 0.4162 mL 0.8323 mL 2.0808 mL
80 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5606 mL
100 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2485 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acamprosate calcium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acamprosate77337-73-6Calcium N-acetylhomotaurinateGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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