2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. Acriflavine

Acriflavine  (Synonyms: Acriflavinium chloride 3,6-Acridinediamine mix)

Cat. No.: HY-100575 Purity: ≥98.0%
Data Sheet
SDS
COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

For research use only. We do not sell to patients.

Acriflavine Chemical Structure

Acriflavine Chemical Structure

CAS No. : 8048-52-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in Water USD 69 In-stock
Solid
100 mg USD 63 In-stock
200 mg   Get quote  
500 mg   Get quote  

Get it by April 8 for select sizes. Order within 10 hrs 34 mins.

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Customer Review

Based on 6 publication(s) in Google Scholar

Other Forms of Acriflavine:

Acriflavine Related Antibodies

Top Publications Citing Use of Products

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HIF-1α HIF

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

In Vitro

Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines[1].
The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acriflavine Related Antibodies
In Vivo

Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization[1].
In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance[2].
Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT03379389Fundação Educacional Serra dos Órgãos
Urinary Tract Infections
March 31, 2018Phase 4
Molecular Weight

259.73

Formula

C14H14ClN3
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

NC(C=C1)=CC(C1=C2)=NC3=C2C=CC(N)=C3.NC(C=C4)=CC(C4=C5)=[N+](C)C6=C5C=CC(N)=C6.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : ≥ 25 mg/mL (96.25 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8502 mL 19.2508 mL 38.5015 mL
5 mM 0.7700 mL 3.8502 mL 7.7003 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 2 mg/mL (7.70 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.8502 mL 19.2508 mL 38.5015 mL 96.2538 mL
5 mM 0.7700 mL 3.8502 mL 7.7003 mL 19.2508 mL
10 mM 0.3850 mL 1.9251 mL 3.8502 mL 9.6254 mL
15 mM 0.2567 mL 1.2834 mL 2.5668 mL 6.4169 mL
20 mM 0.1925 mL 0.9625 mL 1.9251 mL 4.8127 mL
25 mM 0.1540 mL 0.7700 mL 1.5401 mL 3.8502 mL
30 mM 0.1283 mL 0.6417 mL 1.2834 mL 3.2085 mL
40 mM 0.0963 mL 0.4813 mL 0.9625 mL 2.4063 mL
50 mM 0.0770 mL 0.3850 mL 0.7700 mL 1.9251 mL
60 mM 0.0642 mL 0.3208 mL 0.6417 mL 1.6042 mL
80 mM 0.0481 mL 0.2406 mL 0.4813 mL 1.2032 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acriflavine Related Classifications

Keywords:

Acriflavine8048-52-0Acriflavinium chloride 3,6-Acridinediamine mixHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHInhibitorinhibitorinhibit

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