Angiotensin II (3-8), human TFA

Name: Angiotensin II (3-8), human TFA
Brand: MedChemExpress
SKU: HY-P1515A
Rating: 5.0 (2 reviews)

Cat. No.: HY-P1515A Purity: 99.90%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT₁ receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angiotensin II (3-8), human TFA Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 310	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Angiotensin II (3-8), human TFA:

Angiotensin II (3-8), human Get quote

2 Publications Citing Use of MCE Angiotensin II (3-8), human TFA

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT₁ receptor.

IC₅₀ & Target

Angiotensin AT₁ receptor^[1].

In Vivo

Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

888.93

Formula

C₄₂H₅₅F₃N₈O₁₀

Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (56.25 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1249 mL	5.6247 mL	11.2495 mL
5 mM	0.2250 mL	1.1249 mL	2.2499 mL
10 mM	0.1125 mL	0.5625 mL	1.1249 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (260 KB) LCMS (91 KB) Elemental Analysis Report (120 KB)

Handling Instructions (2659 KB)

References

[1]. Gardiner SM, et al. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol. 1993 Sep;110(1):159-62. [Content Brief]

Animal Administration
^[1]

Rats^[1]
Male Long Evans rats (350-450 g) (n=7) are given increasing bolus doses of AII (1.25, 12.5 and 125 pmol/kg) or human Angiotensin II (3-8) (0.125, 1.25 and 12.5 nmol/kg) in random order, in the morning or afternoon of the same experimental day. Injections are separated by at least 20 min to allow variables to return to baseline^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Gardiner SM, et al. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol. 1993 Sep;110(1):159-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.1249 mL	5.6247 mL	11.2495 mL	28.1237 mL
	5 mM	0.2250 mL	1.1249 mL	2.2499 mL	5.6247 mL
	10 mM	0.1125 mL	0.5625 mL	1.1249 mL	2.8124 mL
	15 mM	0.0750 mL	0.3750 mL	0.7500 mL	1.8749 mL
	20 mM	0.0562 mL	0.2812 mL	0.5625 mL	1.4062 mL
	25 mM	0.0450 mL	0.2250 mL	0.4500 mL	1.1249 mL
	30 mM	0.0375 mL	0.1875 mL	0.3750 mL	0.9375 mL
	40 mM	0.0281 mL	0.1406 mL	0.2812 mL	0.7031 mL
	50 mM	0.0225 mL	0.1125 mL	0.2250 mL	0.5625 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.