Autocamtide-2-related inhibitory peptide TFA

Name: Autocamtide-2-related inhibitory peptide TFA
Brand: MedChemExpress
SKU: HY-P0214A
Rating: 5.0 (2 reviews)

Cat. No.: HY-P0214A Purity: 95.24%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Autocamtide-2-related inhibitory peptide TFA Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 728	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Autocamtide-2-related inhibitory peptide TFA:

Autocamtide-2-related inhibitory peptide Get quote

2 Publications Citing Use of MCE Autocamtide-2-related inhibitory peptide TFA

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All CaMK Isoform Specific Products:

View All Isoforms

CaMK III CaMK II

Biological Activity
Purity & Documentation
References
Customer Review

Description

Autocamtide-2-related inhibitory peptide (TFA) is a highly specific and potent inhibitor of CaMKII with an IC₅₀ of 40 nM.

IC₅₀ & Target

CaMK II

In Vitro

It is found that Autocamtide-2-related inhibitory peptide (TFA) is a potent inhibitor of CaM-kinase II with an IC₅₀ of 40 nM, which is active in the presence or absence of Ca²⁺/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93, respectively, under the assay condition used^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1611.76

Formula

C₆₆H₁₂₆N₂₂O₂₁F₃

Appearance

Solid

Color

White to off-white

Sequence

Lys-Lys-Ala-Lru-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Sequence Shortening

KKALRRQEAVDAL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 110 mg/mL (68.25 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.6204 mL	3.1022 mL	6.2044 mL
5 mM	0.1241 mL	0.6204 mL	1.2409 mL
10 mM	0.0620 mL	0.3102 mL	0.6204 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (31.02 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 95.24%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (241 KB) RP-HPLC (151 KB)

Handling Instructions (2659 KB)

References

[1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.6204 mL	3.1022 mL	6.2044 mL	15.5110 mL
	5 mM	0.1241 mL	0.6204 mL	1.2409 mL	3.1022 mL
	10 mM	0.0620 mL	0.3102 mL	0.6204 mL	1.5511 mL
	15 mM	0.0414 mL	0.2068 mL	0.4136 mL	1.0341 mL
	20 mM	0.0310 mL	0.1551 mL	0.3102 mL	0.7755 mL
	25 mM	0.0248 mL	0.1241 mL	0.2482 mL	0.6204 mL
	30 mM	0.0207 mL	0.1034 mL	0.2068 mL	0.5170 mL
	40 mM	0.0155 mL	0.0776 mL	0.1551 mL	0.3878 mL
	50 mM	0.0124 mL	0.0620 mL	0.1241 mL	0.3102 mL
	60 mM	0.0103 mL	0.0517 mL	0.1034 mL	0.2585 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.