CP-809101 hydrochloride

Name: CP-809101 hydrochloride
Brand: MedChemExpress
SKU: HY-15543A
Rating: 4.5 (1 reviews)

Cat. No.: HY-15543A Purity: 99.37%: FAQs
Data Sheet SDS COA Handling Instructions

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CP-809101 hydrochloride is a potent and highly selective 5-HT_2C receptor agonist, with pEC₅₀s of 9.96, 7.19 and 6.81 M for human 5HT_2C, 5HT_2B and 5HT_2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.

For research use only. We do not sell to patients.

CP-809101 hydrochloride Chemical Structure

CAS No. : 1215721-40-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 149	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 149	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	USD 136	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 857	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CP-809101 hydrochloride:

CP-809101 Get quote

1 Publications Citing Use of MCE CP-809101 hydrochloride

•Brain. 2024 May 3:awae143. [Abstract]

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•Related Screening Libraries:

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•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

5-HT_2C Receptor

9.96 (pEC₅₀)

5-HT_2B Receptor

7.19 (pEC₅₀)

5-HT_2A Receptor

6.81 (pEC₅₀)

In Vivo

CP-809101 hydrochloride (0.1-56 mg/kg; s.c.; single) inhibits the conditioned avoidance response of rats in a dose-dependent manner^[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)^[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED₅₀ value of 2.2 mg/kg^[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male CF rats (conditioned avoidance responding (CAR) model)^[1].
Dosage:	0.1-56 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID₅₀ value of 4.8 mg/kg.

Animal Model:	Male CD rats (PCP or d-amphetamine-induced hyperactivity model)^[1].
Dosage:	0.56, 1.78, 5.6, 17.8 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Antagonized PCP-induced hyperactivity, with an ED₅₀ value of 2.4 mg/kg. Antagonized d-amphetamine-induced hyperactivity, with an ED₅₀ value of 2.7 mg/kg, and in a dose-dependent manner.

Animal Model:	Male CD rats (spontaneous locomotor model)^[1].
Dosage:	0.56, 1.78, 5.6, 17.8 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Inhibited spontaneous locomotor activity in a dose-dependent manner (ED₅₀=2.7 mg/kg).

Animal Model:	Adult male Sprague-Dawley rats (280-400 g)^[2].
Dosage:	0.3, 1, 3 mg/kg
Administration:	Subcutaneous injection; single.
Result:	Produced a dose-related decrease in responding for food and nicotine self-administration in rats.

Molecular Weight

341.24

Formula

C₁₅H₁₈Cl₂N₄O

CAS No.

1215721-40-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.ClC1=CC(COC2=NC(N3CCNCC3)=CN=C2)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 20 mg/mL (58.61 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9305 mL	14.6524 mL	29.3049 mL
5 mM	0.5861 mL	2.9305 mL	5.8610 mL
10 mM	0.2930 mL	1.4652 mL	2.9305 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.37%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (245 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. [Content Brief]

[2]. Higgins GA, et al. Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.9305 mL	14.6524 mL	29.3049 mL	73.2622 mL
	5 mM	0.5861 mL	2.9305 mL	5.8610 mL	14.6524 mL
	10 mM	0.2930 mL	1.4652 mL	2.9305 mL	7.3262 mL
	15 mM	0.1954 mL	0.9768 mL	1.9537 mL	4.8841 mL
	20 mM	0.1465 mL	0.7326 mL	1.4652 mL	3.6631 mL
	25 mM	0.1172 mL	0.5861 mL	1.1722 mL	2.9305 mL
	30 mM	0.0977 mL	0.4884 mL	0.9768 mL	2.4421 mL
	40 mM	0.0733 mL	0.3663 mL	0.7326 mL	1.8316 mL
	50 mM	0.0586 mL	0.2930 mL	0.5861 mL	1.4652 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.