2. Membrane Transporter/Ion Channel
  3. CRAC Channel
  4. CRAC intermediate 1

CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9.

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CRAC intermediate 1 Chemical Structure

CRAC intermediate 1 Chemical Structure

CAS No. : 1249343-86-9

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Description

CRAC intermediate 1 is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors, detailed information can be found in Patent WO 2010122089 A1, intermediate 9.

Molecular Weight

223.18

Formula

C10H7F2N3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(F)C=CC=C1F)NC2=NNC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (224.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4807 mL 22.4034 mL 44.8069 mL
5 mM 0.8961 mL 4.4807 mL 8.9614 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4807 mL 22.4034 mL 44.8069 mL 112.0172 mL
5 mM 0.8961 mL 4.4807 mL 8.9614 mL 22.4034 mL
10 mM 0.4481 mL 2.2403 mL 4.4807 mL 11.2017 mL
15 mM 0.2987 mL 1.4936 mL 2.9871 mL 7.4678 mL
20 mM 0.2240 mL 1.1202 mL 2.2403 mL 5.6009 mL
25 mM 0.1792 mL 0.8961 mL 1.7923 mL 4.4807 mL
30 mM 0.1494 mL 0.7468 mL 1.4936 mL 3.7339 mL
40 mM 0.1120 mL 0.5601 mL 1.1202 mL 2.8004 mL
50 mM 0.0896 mL 0.4481 mL 0.8961 mL 2.2403 mL
60 mM 0.0747 mL 0.3734 mL 0.7468 mL 1.8670 mL
80 mM 0.0560 mL 0.2800 mL 0.5601 mL 1.4002 mL
100 mM 0.0448 mL 0.2240 mL 0.4481 mL 1.1202 mL
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CRAC intermediate 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRAC intermediate 11249343-86-9CRAC intermediate1CRAC intermediate-1CRAC ChannelCalcium release-activated channelsCa2+ release-activated Ca2+ channelsInhibitorinhibitorinhibit

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